EHD1 explained

EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1 gene^[1] belonging to the EHD protein family.

Function

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.

Interactions

EHD1 has been shown to interact with Insulin-like growth factor 1 receptor^[2] and SNAP29.^[2]

Further reading

• Di Fiore PP, Pelicci PG, Sorkin A . EH: a novel protein-protein interaction domain potentially involved in intracellular sorting . Trends Biochem. Sci. . 22 . 11 . 411–3 . 1998 . 9397678 . 10.1016/S0968-0004(97)01127-4 .
• Andersson B . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . vanc. Wentland MA . Ricafrente JY . 3 . Liu . W . Gibbs . RA .
• Yu W . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . vanc. Andersson B . Worley KC . 3 . Muzny . DM . Ding . Y . Liu . W . Ricafrente . JY . Wentland . MA . Lennon . G .
• Guru SC . A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus . Genome Res. . 7 . 7 . 725–35 . 1997 . 9253601 . 10.1101/gr.7.7.725. 310681 . vanc. Agarwal SK . Manickam P . 3 . Olufemi . SE . Crabtree . JS . Weisemann . JM . Kester . MB . Kim . YS . Wang . Y .
• Mintz L . EHD1--an EH-domain-containing protein with a specific expression pattern . Genomics . 59 . 1 . 66–76 . 1999 . 10395801 . 10.1006/geno.1999.5800 . vanc. Galperin E . Pasmanik-Chor M . 3 . Tulzinsky . Sandra . Bromberg . Yael . Kozak . Christine A. . Joyner . Alexandra . Fein . Amos . Horowitz . Mia .
• Haider NB . Evaluation and molecular characterization of EHD1, a candidate gene for Bardet-Biedl syndrome 1 (BBS1) . Gene . 240 . 1 . 227–32 . 2000 . 10564830 . 10.1016/S0378-1119(99)00395-9 . vanc. Searby C . Galperin E . 3 . Mintz . L. . Horowitz . M. . Stone . E.M. . Sheffield . V.C. .
• Pohl U . EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins . Genomics . 63 . 2 . 255–62 . 2000 . 10673336 . 10.1006/geno.1999.6087 . vanc. Smith JS . Tachibana I . 3 . Ueki . Keisuke . Lee . Hyun K. . Ramaswamy . Shivapriya . Wu . Qiang . Mohrenweiser . Harvey W. . Jenkins . Robert B. .
• Rotem-Yehudar R, Galperin E, Horowitz M . Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 . J. Biol. Chem. . 276 . 35 . 33054–60 . 2001 . 11423532 . 10.1074/jbc.M009913200 . free .
• Caplan S . A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane . EMBO J. . 21 . 11 . 2557–67 . 2002 . 12032069 . 10.1093/emboj/21.11.2557 . 126039 . vanc. Naslavsky N . Hartnell LM . 3 . Lodge . R . Polishchuk . RS . Donaldson . JG . Bonifacino . JS .
• Galperin E . EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1 . Traffic . 3 . 8 . 575–89 . 2003 . 12121420 . 10.1034/j.1600-0854.2002.30807.x . vanc. Benjamin S . Rapaport D . 3 . Rotem-Yehudar . Rinat . Tolchinsky . Sandra . Horowitz . Mia . 5998465 . free.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Gevaert K . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . vanc. Goethals M . Martens L . 3 . Van Damme . Jozef . Staes . An . Thomas . Grégoire R. . Vandekerckhove . Joël . 23783563 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Naslavsky N, Boehm M, Backlund PS, Caplan S . Rabenosyn-5 and EHD1 Interact and Sequentially Regulate Protein Recycling to the Plasma Membrane . Mol. Biol. Cell . 15 . 5 . 2410–22 . 2005 . 15020713 . 10.1091/mbc.E03-10-0733 . 404033 .
• Guilherme A, Soriano NA, Furcinitti PS, Czech MP . Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes . J. Biol. Chem. . 279 . 38 . 40062–75 . 2004 . 15247266 . 10.1074/jbc.M401918200 . free .
• Xu Y . Mutually exclusive interactions of EHD1 with GS32 and syndapin II . Mol. Membr. Biol. . 21 . 4 . 269–77 . 2005 . 15371016 . 10.1080/09687680410001716871 . vanc. Shi H . Wei S . 3 . Wong . Siew Heng . Hong . Wanjin . 22820496 . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Lee DW . ATP binding regulates oligomerization and endosome association of RME-1 family proteins . J. Biol. Chem. . 280 . 17 . 17213–20 . 2005 . 15710626 . 10.1074/jbc.M412751200 . vanc. Zhao X . Scarselletta S . 3 . Schweinsberg . PJ . Eisenberg . E . Grant . BD . Greene . LE . free .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.

Notes and References

1. Web site: Entrez Gene: EHD1 EH-domain containing 1.
2. Rotem-Yehudar . R . Galperin E . Horowitz M . Aug 2001 . Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 . J. Biol. Chem. . 276 . 35 . 33054–60 . United States. 0021-9258. 11423532 . 10.1074/jbc.M009913200 . free .