EGR4 explained

Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene.^[1]

EGR-4 is a member of the early growth response (EGF) family of zinc finger transcription factors.

Further reading

• Crosby SD, Veile RA, Donis-Keller H . Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. . Proc. Natl. Acad. Sci. U.S.A. . 89 . 10 . 4739–43 . 1992 . 1584812 . 10.1073/pnas.89.10.4739 . 49159. 1992PNAS...89.4739C . etal. free .
• Hillier LW, Graves TA, Fulton RS . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . etal. free .
• Müller HJ, Skerka C, Bialonski A, Zipfel PF . Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains . Proc. Natl. Acad. Sci. U.S.A. . 88 . 22 . 10079–83 . November 1991 . 1658795 . 52871 . 10.1073/pnas.88.22.10079. 1991PNAS...8810079M . free .
• Decker EL, Nehmann N, Kampen E . Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. . Nucleic Acids Res. . 31 . 3 . 911–21 . 2003 . 12560487 . 10.1093/nar/gkg186 . 149206. etal.
• Liu BC, Zhang J, Wang L . No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. . Prog. Neuropsychopharmacol. Biol. Psychiatry . 34 . 3 . 506–9 . 2010 . 20144677 . 10.1016/j.pnpbp.2010.02.005 . 207409159 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129. etal.
• Holst C, Skerka C, Lichter P . Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. . Hum. Mol. Genet. . 2 . 4 . 367–72 . 1993 . 8504297 . 10.1093/hmg/2.4.367. etal.
• Crosby SD, Puetz JJ, Simburger KS . The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family. . Mol. Cell. Biol. . 11 . 8 . 3835–41 . 1991 . 2072895 . 10.1128/MCB.11.8.3835. 361165. etal.
• Hadziselimovic F, Hadziselimovic NO, Demougin P . EGR4 is a master gene responsible for fertility in cryptorchidism. . Sex Dev . 3 . 5 . 253–63 . 2009 . 19828938 . 10.1159/000249147 . etal. free .

Notes and References

1. Web site: Entrez Gene: early growth response 4.