EGR3 explained

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.^{[1] [2] [3]}

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.

Further reading

• Yamada K . Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia . Proc. Natl. Acad. Sci. U.S.A. . 104 . 8 . 2815–2820 . 2007 . 17360599 . 10.1073/pnas.0610765104 . 1815264 . vanc. Gerber DJ . Iwayama Y . 3 . Ohnishi . T. . Ohba . H. . Toyota . T. . Aruga . J. . Minabe . Y. . Tonegawa . S. . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Yoo YG, Lee MO . Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor . J. Biol. Chem. . 279 . 35 . 36242–36249 . 2004 . 15173177 . 10.1074/jbc.M401290200 . free .
• Inoue A . Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells . J. Mol. Endocrinol. . 32 . 3 . 649–661 . 2005 . 15171706 . 10.1677/jme.0.0320649 . vanc. Omoto Y . Yamaguchi Y . 3 . Kiyama . R . Hayashi . SI . free.
• Liu D . Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1 . Arterioscler. Thromb. Vasc. Biol. . 23 . 11 . 2002–2007 . 2004 . 14525795 . 10.1161/01.ATV.0000098644.03153.6F . vanc. Jia H . Holmes DI . 3 . Stannard . A . Zachary . I . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Tourtellotte WG, Milbrandt J . Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3 . Nat. Genet. . 20 . 1 . 87–91 . 1998 . 9731539 . 10.1038/1757 . 5707748 .
• Morris ME . A screen for genes induced in the suprachiasmatic nucleus by light . Science . 279 . 5356 . 1544–1547 . 1998 . 9488654 . 10.1126/science.279.5356.1544 . vanc. Viswanathan N . Kuhlman S . 3 . Davis . FC . Weitz . CJ . 1998Sci...279.1544M .
• Hillier LD . Generation and analysis of 280,000 human expressed sequence tags . Genome Res. . 6 . 9 . 807–828 . 1997 . 8889549 . 10.1101/gr.6.9.807 . vanc. Lennon G . Becker M . 3 . Bonaldo . M F . Chiapelli . B . Chissoe . S . Dietrich . N . Dubuque . T . Favello . A . free .
• Mages HW . Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells . Int. Immunol. . 5 . 1 . 63–70 . 1993 . 8443122 . 10.1093/intimm/5.1.63 . vanc. Stamminger T . Rilke O . 3 . Bravo . Rodrigo . Kroczek . Richard A. .

Notes and References

1. Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP . EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors . Oncogene . 6 . 6 . 917–28 . Aug 1991 . 1906159 .
2. Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD . HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter . J Biol Chem . 277 . 22 . 19482–19487 . May 2002 . 11909874 . 10.1074/jbc.M201687200 . free .
3. Web site: Entrez Gene: EGR3 early growth response 3.