EGLU explained

EGLU ((2S)-α-ethylglutamic acid) is a drug that is used in neuroscience research. It was one of the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR_2/3), and so has been useful in the characterization and study of this receptor subfamily.^{[1] [2] [3] [4] [5] [6] [7]}

Notes and References

1. Jane DE, Thomas NK, Tse HW, Watkins JC . Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord . Neuropharmacology . 35 . 8 . 1029–35 . 1996 . 9121605 . 10.1016/S0028-3908(96)00048-2 . 6238847 .
2. Huang L, Rowan MJ, Anwyl R . Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro . European Journal of Pharmacology . 366 . 2–3 . 151–8 . February 1999 . 10082195 . 10.1016/S0014-2999(98)00918-2 .
3. Palazzo E, Marabese I, de Novellis V, Oliva P, Rossi F, Berrino L, Rossi F, Maione S . 6 . Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception . Neuropharmacology . 40 . 3 . 319–26 . March 2001 . 11166324 . 10.1016/S0028-3908(00)00160-X . 41189905 .
4. Iserhot C, Gebhardt C, Schmitz D, Heinemann U . Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat . Brain Research . 1027 . 1–2 . 151–60 . November 2004 . 15494166 . 10.1016/j.brainres.2004.08.052 . 33373525 .
5. Cahusac PM, Wan H . Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo . Neuroscience . 146 . 1 . 202–12 . April 2007 . 17346894 . 10.1016/j.neuroscience.2007.01.049 . 37975672 .
6. Kim WY, Vezina P, Kim JH . Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment . Behavioural Brain Research . 191 . 1 . 62–6 . August 2008 . 18433894 . 10.1016/j.bbr.2008.03.010 . 24250755 .
7. Altinbilek B, Manahan-Vaughan D . A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory . Neuroscience . 158 . 1 . 149–58 . January 2009 . 18722513 . 10.1016/j.neuroscience.2008.07.045 . 40251815 .