EGLN3 explained

Egl nine homolog 3 is a protein that in humans is encoded by the EGLN3 gene.^[1] ELGN3 is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.

Further reading

• Semenza GL . HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus . Cell . 107 . 1 . 1–3 . October 2001 . 11595178 . 10.1016/S0092-8674(01)00518-9 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Taylor MS . Characterization and comparative analysis of the EGLN gene family . Gene . 275 . 1 . 125–32 . September 2001 . 11574160 . 10.1016/S0378-1119(01)00633-3 .
• Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ . C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation . Cell . 107 . 1 . 43–54 . October 2001 . 11595184 . 10.1016/S0092-8674(01)00507-4 . free .
• Bruick RK, McKnight SL . A conserved family of prolyl-4-hydroxylases that modify HIF . Science . 294 . 5545 . 1337–40 . November 2001 . 11598268 . 10.1126/science.1066373 . 2001Sci...294.1337B . 9695199 .
• Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hütter J, Schramm M, Flamme I . Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors . Biochemical and Biophysical Research Communications . 296 . 2 . 343–9 . August 2002 . 12163023 . 10.1016/S0006-291X(02)00862-8 .
• Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J . Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing . Journal of Cell Science . 116 . Pt 7 . 1319–26 . April 2003 . 12615973 . 10.1242/jcs.00318 . 13698068 .
• Cioffi CL, Liu XQ, Kosinski PA, Garay M, Bowen BR . Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells . Biochemical and Biophysical Research Communications . 303 . 3 . 947–53 . April 2003 . 12670503 . 10.1016/S0006-291X(03)00453-4 .
• Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC . Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors . Journal of Cellular Biochemistry . 92 . 3 . 491–501 . June 2004 . 15156561 . 10.1002/jcb.20067 . 24455956 .
• Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM . Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor . The Journal of Biological Chemistry . 279 . 37 . 38458–65 . September 2004 . 15247232 . 10.1074/jbc.M406026200 . free .
• Masson N, Appelhoff RJ, Tuckerman JR, Tian YM, Demol H, Puype M, Vandekerckhove J, Ratcliffe PJ, Pugh CW . The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin . FEBS Letters . 570 . 1–3 . 166–70 . July 2004 . 15251459 . 10.1016/j.febslet.2004.06.040 . free .
• Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL . OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha . Molecular Cell . 17 . 4 . 503–12 . February 2005 . 15721254 . 10.1016/j.molcel.2005.01.011 . free .
• Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S . Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer . Cancer Cell . 8 . 2 . 155–67 . August 2005 . 16098468 . 10.1016/j.ccr.2005.06.015 . free .
• Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G . The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3) . The Journal of Biological Chemistry . 281 . 13 . 8645–55 . March 2006 . 16407229 . 10.1074/jbc.M513751200 . free .
• Nakayama K, Gazdoiu S, Abraham R, Pan ZQ, Ronai Z . Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2 . The Biochemical Journal . 401 . 1 . 217–26 . January 2007 . 16958618 . 1698661 . 10.1042/BJ20061135 .

Notes and References

1. Web site: Entrez Gene: EGLN3 egl nine homolog 3 (C. elegans).