EGIS-7625 explained

EGIS-7625 is a selective and competitive 5-HT2B receptor antagonist. It is experimentally proven to be directly associated with smooth stomach muscle constriction of white rats in vivo, and variably effective in provoking a similar response in in vitro human stomach cells. In high blood concentrations, it causes mild constriction of rabbit pulmonary arteries.[1]

Notes and References

  1. Kovács A, Gacsályi I, Wellmann J, Schmidt E, Szücs Z, Dubreuil V, Nicolas JP, Boutin J, Bózsing D, Egyed A, Tihanyi K, Spedding M, Szénási G . 11532969 . 6 . Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist . Cardiovascular Drugs and Therapy . 17 . 5–6 . 427–34 . 2003 . 15107597 . 10.1023/B:CARD.0000015857.96371.43 .

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