EG-018 explained

EG-018 is a carbazole-based synthetic cannabinoid that has been sold online as a designer drug.^{[1] [2] [3] [4] [5]} It acts as a partial agonist of the CB₁ and CB₂ receptor, with reasonably high binding affinity, but low efficacy in terms of inducing a signaling response.^[6]

Legal status

EG-018 is a controlled substance in Japan.^[7]

Notes and References

1. Web site: EG 018. www.caymanchem.com.
2. Mogler L, Franz F, Wilde M, Huppertz LM, Halter S, Angerer V, Moosmann B, Auwärter V . 6 . Phase I metabolism of the carbazole-derived synthetic cannabinoids EG-018, EG-2201, and MDMB-CHMCZCA and detection in human urine samples . Drug Testing and Analysis . 10 . 9 . 1417–1429 . September 2018 . 29726116 . 10.1002/dta.2398 .
3. Book: Banister SD, Connor M . New Psychoactive Substances. The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution. Springer International Publishing. August 2018. 978-3-030-10561-7. 191–226. Handbook of Experimental Pharmacology. 252. Springer Link. 10.1007/164_2018_144. 30105473.
4. Gaunitz F, Dahm P, Mogler L, Thomas A, Thevis M, Mercer-Chalmers-Bender K . In vitro metabolic profiling of synthetic cannabinoids by pooled human liver microsomes, cytochrome P450 isoenzymes, and Cunninghamella elegans and their detection in urine samples . Analytical and Bioanalytical Chemistry . 411 . 16 . 3561–3579 . June 2019 . 31183523 . 10.1007/s00216-019-01837-8 . 184487406 .
5. Diao X, Carlier J, Zhu M, Huestis MA . Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry. Forensic Toxicology. July 2018. 1860-8973. 304–312. 36. 2. 10.1007/s11419-018-0404-2. 44196013.
6. Gamage TF, Barrus DG, Kevin RC, Finlay DB, Lefever TW, Patel PR, Grabenauer MA, Glass M, McGregor IS, Wiley JL, Thomas BF . 6 . In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018 . Pharmacology, Biochemistry, and Behavior . 193 . 172918 . June 2020 . 32247816 . 10.1016/j.pbb.2020.172918 . 7239729 .
7. Web site: 指定薬物を指定する省令が公布されました｜厚生労働省. Ministry of Health, Labour and Welfare. ja. www.mhlw.go.jp.