EEM (2,4-diethoxy-5-methoxyamphetamine) is a lesser-known substituted amphetamine. It is a diethoxy-methoxy analog of trimethoxyamphetamine (TMA-2). EEM was first synthesized by Alexander Shulgin. In his book PiHKAL, both the dosage and duration are unknown.[1] EEM produces few to no effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of EEM.