N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline explained

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) is an irreversible dopamine-receptor antagonist.[1]

EEDQ is also a highly specific reagent for carboxyl groups. It enables the coupling of acylamino acids with amino acid esters in high yield and without racemization.[2]

It is also an irreversible dopamine transporter (DAT) blocker in vitro, though it is ineffective in vivo.[3]

Notes and References

  1. Neuroscience Letters 1992, 137(2), p.265
  2. https://www.bachem.com/
  3. Tarazi FI, Kula NS, Zhang K, Baldessarini RJ . Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ . Neuropharmacology . 39 . 11 . 2133–8 . August 2000 . 10963756 . 10.1016/s0028-3908(00)00047-2 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2025, A B Cryer, All Rights Reserved. Cookie policy.