EDIL3 explained

EGF like repeats and discoidin domains 3 is a protein that in humans is encoded by the EDIL3 gene.^[1]

Function

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior.

Further reading

• Rezaee M, Penta K, Quertermous T . Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3) . Am. J. Physiol. Heart Circ. Physiol. . 282 . 5 . H1924–32 . 2002 . 11959660 . 10.1152/ajpheart.00921.2001 .
• Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T . The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation . Microvascular Research . 64 . 1 . 148–61 . 2002 . 12074641 . 10.1006/mvre.2002.2414 .
• Niu JX, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN . The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion . Eur. J. Cancer Prev. . 16 . 6 . 517–27 . 2007 . 18090124 . 10.1097/CEJ.0b013e3280145c00 . 1825380 .
• Zou X, Qiao H, Jiang X, Dong X, Jiang H, Sun X . Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer . J. Biomed. Sci. . 16 . 33 . 2009 . 1 . 19292890 . 2666667 . 10.1186/1423-0127-16-33 . free .
• Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK . The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations . Hum. Genet. . 126 . 5 . 655–66 . 2009 . 19578876 . 2783187 . 10.1007/s00439-009-0714-x .
• Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB . Chemerin, a novel adipokine in the regulation of angiogenesis . J. Clin. Endocrinol. Metab. . 95 . 5 . 2476–85 . 2010 . 20237162 . 2869547 . 10.1210/jc.2010-0042 .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Sun JC, Liang XT, Pan K, Wang H, Zhao JJ, Li JJ, Ma HQ, Chen YB, Xia JC . High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients . World J. Gastroenterol. . 16 . 36 . 4611–5 . 2010 . 20857535 . 2945496 . 10.3748/wjg.v16.i36.4611 . free .
• Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF . A genome-wide study reveals copy number variants exclusive to childhood obesity cases . Am. J. Hum. Genet. . 87 . 5 . 661–6 . 2010 . 20950786 . 2978976 . 10.1016/j.ajhg.2010.09.014 .

Notes and References

1. Web site: Entrez Gene: EGF like repeats and discoidin domains 3. 2017-07-24.