EDEM3 explained

ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene.^{[1] [2] [3]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Sood R, Bonner TI, Makalowska I . Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus . Genomics . 73 . 2 . 211–22 . 2001 . 11318611 . 10.1006/geno.2001.6500 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Hirao K, Natsuka Y, Tamura T . EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming . J. Biol. Chem. . 281 . 14 . 9650–8 . 2006 . 16431915 . 10.1074/jbc.M512191200 . etal. free .
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .

Notes and References

1. Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW . Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins . Glycobiology . 15 . 4 . 421–36 . Mar 2005 . 15537790 . 10.1093/glycob/cwi014 .
2. Olivari S, Galli C, Alanen H, Ruddock L, Molinari M . A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation . J Biol Chem . 280 . 4 . 2424–8 . Jan 2005 . 15579471 . 10.1074/jbc.C400534200 . free.
3. Web site: Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3.