EDEM1 explained

ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.^{[1] [2]}

Further reading

• Nagase T, Seki N, Ishikawa K . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. . DNA Res. . 3 . 5 . 321–9, 341–54 . 1997 . 9039502 . 10.1093/dnares/3.5.321 . etal. free .
• Hosokawa N, Wada I, Hasegawa K . A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. . EMBO Rep. . 2 . 5 . 415–22 . 2001 . 11375934 . 10.1093/embo-reports/kve084 . 1083879 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Oda Y, Hosokawa N, Wada I, Nagata K . EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin. . Science . 299 . 5611 . 1394–7 . 2003 . 12610305 . 10.1126/science.1079181 . 28716209 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Olivari S, Galli C, Alanen H . A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation. . J. Biol. Chem. . 280 . 4 . 2424–8 . 2005 . 15579471 . 10.1074/jbc.C400534200 . etal. free .
• Oda Y, Okada T, Yoshida H . Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. . J. Cell Biol. . 172 . 3 . 383–93 . 2006 . 16449189 . 10.1083/jcb.200507057 . 2063648 . etal.
• Hosokawa N, Wada I, Natsuka Y, Nagata K . EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin. . Genes Cells . 11 . 5 . 465–76 . 2006 . 16629899 . 10.1111/j.1365-2443.2006.00957.x . 19832510 . free .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.
• Zuber C, Cormier JH, Guhl B . EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites. . Proc. Natl. Acad. Sci. U.S.A. . 104 . 11 . 4407–12 . 2007 . 17360537 . 10.1073/pnas.0700154104 . 1810509 . 2007PNAS..104.4407Z . etal. free .

Notes and References

1. Molinari M, Calanca V, Galli C, Lucca P, Paganetti P . Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle . Science . 299 . 5611 . 1397–400 . Feb 2003 . 12610306 . 10.1126/science.1079474 . 24092303 .
2. Web site: Entrez Gene: EDEM1 ER degradation enhancer, mannosidase alpha-like 1.