EDC3 explained

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.^{[1] [2] [3]}

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . Yoshitomo-Nakagawa K . Maruyama K . Suyama . Akira . Sugano . Sumio .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Jin J . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . Smith FD . Stark C . Wells . Clark D. . Fawcett . James P. . Kulkarni . Sarang . Metalnikov . Pavel . O'Donnell . Paul . Taylor . Paul . 2371325 . free . 2004CBio...14.1436J .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Wan D . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842 . Gong Y . Qin W . Zhang . P . Li . J . Wei . L . Zhou . X . Li . H . Qiu . X . 2004PNAS..10115724W . free .
• Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J . Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping . Mol. Cell . 20 . 6 . 905–15 . 2006 . 16364915 . 10.1016/j.molcel.2005.10.031 . free .
• Beausoleil SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . Villén J . Gerber SA . Rush . John . Gygi . Steven P . 14294292 .
• Ewing RM . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . Chu P . Elisma F . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .
• Tritschler F . A Divergent Sm Fold in EDC3 Proteins Mediates DCP1 Binding and P-Body Targeting . Mol. Cell. Biol. . 27 . 24 . 8600–11 . 2007 . 17923697 . 10.1128/MCB.01506-07 . 2169425 . Eulalio A . Truffault V . Hartmann . M. D. . Helms . S. . Schmidt . S. . Coles . M. . Izaurralde . E. . Weichenrieder . O. .

Notes and References

1. Albrecht M, Lengauer T . Novel Sm-like proteins with long C-terminal tails and associated methyltransferases . FEBS Lett . 569 . 1–3 . 18–26 . Jun 2004 . 15225602 . 10.1016/j.febslet.2004.03.126 . free .
2. Rudolph C, Sigruener A, Hartmann A, Orso E, Bals-Pratsch M, Gronwald W, Seifert B, Kalbitzer HR, Verdorfer I, Luetjens CM, Ortmann O, Bornstein SR, Schmitz G . ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis . Horm Metab Res . 39 . 5 . 322–35 . May 2007 . 17533573 . 10.1055/s-2007-977699 . 10679128 .
3. Web site: Entrez Gene: EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae).