UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate ligase explained

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase
Ec Number:	6.3.2.13
Cas Number:	2620865

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase (MurE synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming), UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase, UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase) is an enzyme with systematic name UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate

\rightleftharpoons ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate

This enzyme takes part in synthesis of a cell-wall peptide.

Notes and References

1. Mizuno Y, Ito E . Purification and properties of uridine diphosphate N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase . The Journal of Biological Chemistry . 243 . 10 . 2665–72 . May 1968 . 4967958 .
2. van Heijenoort J . Recent advances in the formation of the bacterial peptidoglycan monomer unit . Natural Product Reports . 18 . 5 . 503–19 . October 2001 . 11699883 . 10.1039/a804532a .