Pyroglutamyl-peptidase I explained

Pyroglutamyl-peptidase I
Ec Number:	3.4.19.3
Cas Number:	9075-21-2

Pyroglutamyl-peptidase I (also known as Pyrrolidonyl peptidase, is an enzyme (a cysteine peptidase) found in bacteria, plants and animals.

It can be used to distinguish certain Streptococcal organisms.^[1]

Other names are 5-oxoprolyl-peptidase, pyrase, pyrrolidonyl arylamidase, pyroglutamate aminopeptidase, pyroglutamyl aminopeptidase, L-pyroglutamyl peptide hydrolase, pyrrolidone-carboxyl peptidase, pyrrolidone-carboxylate peptidase, pyrrolidonyl peptidase, L-pyrrolidonecarboxylate peptidase, pyroglutamidase, pyrrolidonecarboxylyl peptidase) is an enzyme.^{[2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro

Human gene

PGPEP1

See also

• Pyrrolidonyl-beta-naphthylamide
• P-Dimethylaminocinnamaldehyde
• Pyroglutamic acid
• 2-Naphthylamine

Notes and References

1. Panosian KJ, Edberg SC . Measurement of constitutive L-pyrrolidonyl peptidase activity from Streptococcus and Enterococcus using tetrazotized 0-dianisidine . Antonie van Leeuwenhoek . 55 . 3 . 269–75 . March 1989 . 2569292 . 10.1007/BF00393855.
2. Pyroglutamyl-peptidase from Bacillus amyloliquefaciens. An improved purification method and some properties of the enzyme . Tsuru D, Nakamura K, Yoshimoto T, Fujiwara K . Biochim. Biophys. Acta . 1984 . 791 . 2 . 117–122 . 10.1016/0167-4838(84)90001-3.
3. Awadé AC, Cleuziat P, Gonzalès T, Robert-Baudouy J . Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins . Proteins . 20 . 1 . 34–51 . September 1994 . 7824521 . 10.1002/prot.340200106 .
4. Patti JM, Schneider A, Garza N, Boles JO . Isolation and characterization of pcp, a gene encoding a pyrrolidone carboxyl peptidase in Staphylococcus aureus . Gene . 166 . 1 . 95–9 . December 1995 . 8529900 . 10.1016/0378-1119(95)00561-0 .
5. Le Saux O, Gonzales T, Robert-Baudouy J . Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase . Journal of Bacteriology . 178 . 11 . 3308–13 . June 1996 . 8655512 . 178084 .