N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase explained

N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase
Ec Number:	2.4.1.187
Cas Number:	118731-82-1

N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase (uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase, N-acetylmannosaminyltransferase, UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase, UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol 4-beta-N-acetylmannosaminyltransferase.^[1] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-mannosamine + N-acetyl-D-glucosaminyldiphosphoundecaprenol

\rightleftharpoons UDP + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-D-glucosaminyldiphosphoundecaprenol

This enzyme is involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls.

Notes and References

1. Murazumi N, Kumita K, Araki Y, Ito E . Partial purification and properties of UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferase from Bacillus subtilis . Journal of Biochemistry . 104 . 6 . 980–4 . December 1988 . 2977387 .