Glucosamine-1-phosphate N-acetyltransferase explained

glucosamine-1-phosphate N-acetyltransferase
Ec Number:	2.3.1.157
Go Code:	0019134

In enzymology, a glucosamine-1-phosphate N-acetyltransferase is an enzyme that catalyzes the chemical reaction

acetyl-CoA + alpha-D-glucosamine 1-phosphate

\rightleftharpoons CoA + N-acetyl-alpha-D-glucosamine 1-phosphate

Thus, the two substrates of this enzyme are acetyl-CoA and alpha-D-glucosamine 1-phosphate, whereas its two products are CoA and N-acetyl-alpha-D-glucosamine 1-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and .

References

• Mengin-Lecreulx D, van Heijenoort J . 1994 . Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis . J. Bacteriol. . 176 . 5788 - 95 . 8083170 . 18 . 10.1128/jb.176.18.5788-5795.1994 . 196783 .