Short-chain acyl-CoA dehydrogenase explained

Short-chain acyl-CoA dehydrogenase
Ec Number:1.3.8.1
Cas Number:9027-88-7
Width:270

Short-chain acyl-CoA dehydrogenase (butyryl-CoA dehydrogenase, butanoyl-CoA dehydrogenase, butyryl dehydrogenase, unsaturated acyl-CoA reductase, ethylene reductase, enoyl-coenzyme A reductase, unsaturated acyl coenzyme A reductase, butyryl coenzyme A dehydrogenase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, 3-hydroxyacyl CoA reductase, butanoyl-CoA:(acceptor) 2,3-oxidoreductase, ACADS (gene).) is an enzyme with systematic name short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase.[1] [2] [3] [4] [5] [6] [7] This enzyme catalyses the following chemical reaction

\rightleftharpoons

a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein

This enzyme contains FAD as prosthetic group.

See also

Notes and References

  1. Mahler HR . Studies on the fatty acid oxidizing system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase . The Journal of Biological Chemistry . 206 . 1 . 13–26 . January 1954 . 10.1016/S0021-9258(18)71291-X . 13130522 . free .
  2. Green DE, Mii S, Mahler HR, Bock RM . Studies on the fatty acid oxidizing system of animal tissues. III. Butyryl coenzyme A dehydrogenase . The Journal of Biological Chemistry . 206 . 1 . 1–12 . January 1954 . 10.1016/S0021-9258(18)71290-8 . 13130521 . free .
  3. Book: Acyl coenzyme A dehydrogenase . The Enzymes . Beinert H . 1963 . 7 . 447–466 . Boyer PD, Lardy H, Myrbäck K . 2nd . Academic Press . New York .
  4. Shaw L, Engel PC . The purification and properties of ox liver short-chain acyl-CoA dehydrogenase . The Biochemical Journal . 218 . 2 . 511–20 . March 1984 . 6712627 . 1153367 . 10.1042/bj2180511.
  5. Thorpe C, Kim JJ . Structure and mechanism of action of the acyl-CoA dehydrogenases . FASEB Journal . 9 . 9 . 718–25 . June 1995 . 7601336 . 10.1096/fasebj.9.9.7601336. free . 42549744 .
  6. Ikeda Y, Okamura-Ikeda K, Tanaka K . Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme . The Journal of Biological Chemistry . 260 . 2 . 1311–25 . January 1985 . 10.1016/S0021-9258(20)71245-7 . 3968063 . free .
  7. McMahon B, Gallagher ME, Mayhew SG . The protein coded by the PP2216 gene of Pseudomonas putida KT2440 is an acyl-CoA dehydrogenase that oxidises only short-chain aliphatic substrates . FEMS Microbiology Letters . 250 . 1 . 121–7 . September 2005 . 16024185 . 10.1016/j.femsle.2005.06.049 . free .

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