ECEL1 explained

Endothelin-converting enzyme-like 1 is a protein that in humans is encoded by the ECEL1 gene.^{[1] [2] [3]}

This gene encodes a member of the neutral endopeptidase (NEP)-related family. It is expressed specifically in the nervous system. The gene disruption in mouse embryonic stem cells results in neonatal lethality due to respiratory failure shortly after birth. Based on the specific expression of this gene and the phenotype of the gene deficiency in mouse embryos, it is suggested that the protein encoded by this gene play a critical role in the nervous regulation of the respiratory system.^[4]

Further reading

• Valdenaire O, Rohrbacher E, Langeveld A . Organization and chromosomal localization of the human ECEL1 (XCE) gene encoding a zinc metallopeptidase involved in the nervous control of respiration. . Biochem. J. . 346 Pt 3 . 3. 611–6 . 2000 . 10698686 . 10.1042/0264-6021:3460611 . 1220892 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Kawamoto T, Ohira M, Hamano S . High expression of the novel endothelin-converting enzyme genes, Nbla03145/ECEL1alpha and beta, is associated with favorable prognosis in human neuroblastomas. . Int. J. Oncol. . 22 . 4 . 815–22 . 2003 . 12632073 . 10.3892/ijo.22.4.815. etal.
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Benoit A, Vargas MA, Desgroseillers L, Boileau G . Endothelin-converting enzyme-like 1 (ECEL1) is present both in the plasma membrane and in the endoplasmic reticulum. . Biochem. J. . 380 . Pt 3 . 881–8 . 2004 . 14992683 . 10.1042/BJ20040215 . 1224203 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Hillier LW, Graves TA, Fulton RS . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . etal. free .

Notes and References

1. Valdenaire O, Richards JG, Faull RL, Schweizer A . XCE, a new member of the endothelin-converting enzyme and neutral endopeptidase family, is preferentially expressed in the CNS . Brain Res Mol Brain Res . 64 . 2 . 211–21 . Mar 1999 . 9931490 . 10.1016/S0169-328X(98)00321-0 .
2. Rump A, Kasper G, Hayes C, Wen G, Starke H, Liehr T, Lehmann R, Lagemann D, Rosenthal A . Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1 . Genomics . 73 . 1 . 50–5 . May 2001 . 11352565 . 10.1006/geno.2000.6504 .
3. Web site: Entrez Gene: ECEL1 endothelin converting enzyme-like 1.
4. Web site: Entrez Gene: ECEL1 endothelin converting enzyme-like 1.