Endothelin converting enzyme 1 explained

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.^{[1] [2] [3]}

Function

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.

Further reading

• Yorimitsu K, Moroi K, Inagaki N . Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2 . Biochem. Biophys. Res. Commun. . 208 . 2 . 721–7 . 1995 . 7695628 . 10.1006/bbrc.1995.1397 . etal.
• Schmidt M, Kröger B, Jacob E . Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) . FEBS Lett. . 356 . 2–3 . 238–43 . 1995 . 7805846 . 10.1016/0014-5793(94)01277-6 . etal. free .
• Shimada K, Matsushita Y, Wakabayashi K . Cloning and functional expression of human endothelin-converting enzyme cDNA . Biochem. Biophys. Res. Commun. . 207 . 2 . 807–12 . 1995 . 7864876 . 10.1006/bbrc.1995.1258 . etal.
• Valdenaire O, Rohrbacher E, Mattei MG . Organization of the gene encoding the human endothelin-converting enzyme (ECE-1) . J. Biol. Chem. . 270 . 50 . 29794–8 . 1996 . 8530372 . 10.1074/jbc.270.50.29794 . free .
• Matsuoka R, Sawamura T, Yamada K . Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1 . Cytogenet. Cell Genet. . 72 . 4 . 322–4 . 1996 . 8641140 . 10.1159/000134214 . etal.
• Orzechowski HD, Richter CM, Funke-Kaiser H . Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells . J. Mol. Med. . 75 . 7 . 512–21 . 1997 . 9253714 . 10.1007/s001090050136 . 34633812 . etal.
• Schweizer A, Valdenaire O, Nelböck P . Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations . Biochem. J. . 328 . Pt 3. 871–7 . 1998 . 9396733 . 10.1042/bj3280871. 1218999 . etal.
• Kido T, Sawamura T, Masaki T . The processing pathway of endothelin-1 production . J. Cardiovasc. Pharmacol. . 31 . S13–5 . 1998 . Suppl 1 . 9595387 . 10.1097/00005344-199800001-00006 . free .
• Hofstra RM, Valdenaire O, Arch E . A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction . Am. J. Hum. Genet. . 64 . 1 . 304–8 . 1999 . 9915973 . 10.1086/302184 . 1377732 . etal.
• Lee S, Lin M, Mele A . Proteolytic processing of big endothelin-3 by the kell blood group protein . Blood . 94 . 4 . 1440–50 . 1999 . 10438732 . 10.1182/blood.V94.4.1440. etal.
• Valdenaire O, Lepailleur-Enouf D, Egidy G . A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization . Eur. J. Biochem. . 264 . 2 . 341–9 . 1999 . 10491078 . 10.1046/j.1432-1327.1999.00602.x . etal. free .
• Fahnoe DC, Johnson GD, Herman SB, Ahn K . Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells . Arch. Biochem. Biophys. . 373 . 2 . 385–93 . 2000 . 10620363 . 10.1006/abbi.1999.1586 .
• López-Ongil S, Senchak V, Saura M . Superoxide regulation of endothelin-converting enzyme . J. Biol. Chem. . 275 . 34 . 26423–7 . 2000 . 10833511 . 10.1074/jbc.M000767200 . etal. free .
• Hachiya A, Kobayashi T, Takema Y, Imokawa G . Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis . J. Biol. Chem. . 277 . 7 . 5395–403 . 2002 . 11723113 . 10.1074/jbc.M105874200 . free .
• Inguimbert N, Coric P, Poras H . Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP) . J. Med. Chem. . 45 . 7 . 1477–86 . 2002 . 11906289 . 10.1021/jm0005454 . etal.
• MacLeod KJ, Husain RD, Gage DA, Ahn K . Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms . J. Biol. Chem. . 277 . 48 . 46355–63 . 2003 . 12244060 . 10.1074/jbc.M207972200 . free .
• Muller L, Barret A, Etienne E . Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease . J. Biol. Chem. . 278 . 1 . 545–55 . 2003 . 12393864 . 10.1074/jbc.M208949200 . etal. free .
• Eckman EA, Watson M, Marlow L . Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme . J. Biol. Chem. . 278 . 4 . 2081–4 . 2003 . 12464614 . 10.1074/jbc.C200642200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Masatsugu K, Itoh H, Chun TH . Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress . Regul. Pept. . 111 . 1–3 . 13–9 . 2003 . 12609744 . 10.1016/S0167-0115(02)00219-7 . etal. 2433/147555 . 37039969 . free .
• Smollich M, Götte M, Yip GW . On the role of endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer . Breast Cancer Res. Treat. . 106 . 3 . 361–9 . 2007 . 17295044 . 10.1007/s10549-007-9516-9 . 5546294 . etal.

Notes and References

1. Web site: Entrez Gene: ECE1 endothelin converting enzyme 1.
2. Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H . Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) . FEBS Lett. . 356 . 2–3 . 238–43 . December 1994 . 7805846 . 10.1016/0014-5793(94)01277-6. free .
3. Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K . Cloning and functional expression of human endothelin-converting enzyme cDNA . Biochem. Biophys. Res. Commun. . 207 . 2 . 807–12 . February 1995 . 7864876 . 10.1006/bbrc.1995.1258 .