EBF1 explained

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.^{[1] [2] [3]}

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.^{[4] [5]} The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.^[6] In addition, EBF1 is also noted for its role in chondrogenic differentiation in limb bud mesenchymal progenitor cells.^[7]

Interactions

EBF1 has been shown to interact with ZNF423^[8] and CREB binding protein.^[9]

References

Further reading

• Liberg D, Sigvardsson M, Akerblad P . The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers . Molecular and Cellular Biology . 22 . 24 . 8389–8397 . December 2002 . 12446759 . 139877 . 10.1128/MCB.22.24.8389-8397.2002 .
• Hagman J, Gutch MJ, Lin H, Grosschedl R . EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains . The EMBO Journal . 14 . 12 . 2907–2916 . June 1995 . 7796816 . 398409 . 10.1002/j.1460-2075.1995.tb07290.x .
• Wang MM, Reed RR . Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast . Nature . 364 . 6433 . 121–126 . July 1993 . 8321284 . 10.1038/364121a0 . 4309685 . 1993Natur.364..121W .
• Hagman J, Belanger C, Travis A, Turck CW, Grosschedl R . Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression . Genes & Development . 7 . 5 . 760–773 . May 1993 . 8491377 . 10.1101/gad.7.5.760 . free .
• Travis A, Hagman J, Hwang L, Grosschedl R . Purification of early-B-cell factor and characterization of its DNA-binding specificity . Molecular and Cellular Biology . 13 . 6 . 3392–3400 . June 1993 . 8497258 . 359803 . 10.1128/MCB.13.6.3392 .
• Tsai RY, Reed RR . Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development . The Journal of Neuroscience . 17 . 11 . 4159–4169 . June 1997 . 9151733 . 6573535 . 10.1523/JNEUROSCI.17-11-04159.1997 . free .
• Gisler R, Jacobsen SE, Sigvardsson M . Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse . Blood . 96 . 4 . 1457–1464 . August 2000 . 10942392 . 10.1182/blood.V96.4.1457 . free .
• Gisler R, Sigvardsson M . The human V-preB promoter is a target for coordinated activation by early B cell factor and E47 . Journal of Immunology . 168 . 10 . 5130–5138 . May 2002 . 11994467 . 10.4049/jimmunol.168.10.5130 . free .
• Smith EM, Gisler R, Sigvardsson M . Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression . Journal of Immunology . 169 . 1 . 261–270 . July 2002 . 12077253 . 10.4049/jimmunol.169.1.261 . free .
• Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T . Inhibition of p300/CBP by early B-cell factor . Molecular and Cellular Biology . 23 . 11 . 3837–3846 . June 2003 . 12748286 . 155219 . 10.1128/MCB.23.11.3837-3846.2003 .
• Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, Pucillo C . CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism . The Journal of Biological Chemistry . 279 . 3 . 1777–1786 . January 2004 . 14594818 . 10.1074/jbc.M305418200 . free .
• Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S . Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells . Blood . 103 . 6 . 2062–2070 . March 2004 . 14630787 . 10.1182/blood-2003-07-2388 . free .
• Smith EM, Akerblad P, Kadesch T, Axelson H, Sigvardsson M . Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development . Blood . 106 . 6 . 1995–2001 . September 2005 . 15920012 . 10.1182/blood-2004-12-4744 . free .
• Akerblad P, Månsson R, Lagergren A, Westerlund S, Basta B, Lind U, Thelin A, Gisler R, Liberg D, Nelander S, Bamberg K, Sigvardsson M . Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics . Physiological Genomics . 23 . 2 . 206–216 . October 2005 . 16106032 . 10.1152/physiolgenomics.00015.2005 . 42168486 .
• Martínez A, Mas A, de las Heras V, Arroyo R, Fernández-Arquero M, de la Concha EG, Urcelay E . Early B-cell Factor gene association with multiple sclerosis in the Spanish population . BMC Neurology . 5 . 19 . October 2005 . 16255771 . 1291372 . 10.1186/1471-2377-5-19 . free .
• Roessler S, Györy I, Imhof S, Spivakov M, Williams RR, Busslinger M, Fisher AG, Grosschedl R . Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5 . Molecular and Cellular Biology . 27 . 2 . 579–594 . January 2007 . 17101802 . 1800812 . 10.1128/MCB.01192-06 .

Notes and References

1. Web site: Symbol Report: EBF1. HUGO Gene Nomenclature Committee .
2. Milatovich A, Qiu RG, Grosschedl R, Francke U . Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11 . Mammalian Genome . 5 . 4 . 211–215 . April 1994 . 8012110 . 10.1007/BF00360547 . 19839522 .
3. Web site: Entrez Gene: EBF1 early B-cell factor 1.
4. Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, Grosschedl R . Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin . Immunity . 32 . 5 . 714–725 . May 2010 . 20451411 . 10.1016/j.immuni.2010.04.013 . free .
5. Book: Hagman J, Ramírez J, Lukin K . B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1 . January 2012 . Murre C . Epigenetic Regulation of Lymphocyte Development. Current Topics in Microbiology and Immunology. 356. 17–38. 10.1007/82_2011_139. 0070-217X. 3925327. 21735360. 978-3-642-24102-4.
6. Schwartz AM, Putlyaeva LV, Covich M, Klepikova AV, Akulich KA, Vorontsov IE, Korneev KV, Dmitriev SE, Polanovsky OL, Sidorenko SP, Kulakovskiy IV, Kuprash DV . Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells . Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms . 1859 . 10 . 1259–1268 . October 2016 . 27424222 . 10.1016/j.bbagrm.2016.07.004 .
7. Takács R, Vágó J, Póliska S, Pushparaj PN, Ducza L, Kovács P, Jin EJ, Barrett-Jolley R, Zákány R, Matta C . The temporal transcriptomic signature of cartilage formation . Nucleic Acids Research . 51 . 8 . 3590–3617 . May 2023 . 36987858 . 10164575 . 10.1093/nar/gkad210 .
8. Tsai RY, Reed RR . Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development . The Journal of Neuroscience . 17 . 11 . 4159–4169 . June 1997 . 9151733 . 6573535 . 10.1523/JNEUROSCI.17-11-04159.1997 . free .
9. Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T . Inhibition of p300/CBP by early B-cell factor . Molecular and Cellular Biology . 23 . 11 . 3837–3846 . June 2003 . 12748286 . 155219 . 10.1128/MCB.23.11.3837-3846.2003 .