EBAG9 explained

Receptor-binding cancer antigen expressed on SiSo cells is a protein that in humans is encoded by the EBAG9 gene.

This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.^[1]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Watanabe T . Isolation of Estrogen-Responsive Genes with a CpG Island Library . Mol. Cell. Biol. . 18 . 1 . 442–9 . 1998 . 9418891 . 10.1128/mcb.18.1.442. 121513 . Inoue S . Hiroi H . Orimo . A . Kawashima . H . Muramatsu . M .
• Nakashima M, Sonoda K, Watanabe T . Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1 . Nat. Med. . 5 . 8 . 938–42 . 1999 . 10426319 . 10.1038/11383 . 7513858 .
• Ikeda K . Promoter analysis and chromosomal mapping of human EBAG9 gene . Biochem. Biophys. Res. Commun. . 273 . 2 . 654–60 . 2000 . 10873660 . 10.1006/bbrc.2000.2920 . Sato M . Tsutsumi O . Tsuchiya . Fujiko . Tsuneizumi . Michiko . Emi . Mitsuru . Imoto . Issei . Inazawa . Johji . Muramatsu . Masami .
• Ohshima K . Expression of RCAS1 and FasL in human trophoblasts and uterine glands during pregnancy: the possible role in immune privilege . Clin. Exp. Immunol. . 123 . 3 . 481–6 . 2001 . 11298137 . 10.1046/j.1365-2249.2001.01461.x . 1906005 . Nakashima M . Sonoda K . Kikuchi . M. . Watanabe . T. .
• Matsushima T . Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells . Blood . 98 . 2 . 313–21 . 2001 . 11435298 . 10.1182/blood.V98.2.313.h8000313_313_321 . Nakashima M . Oshima K . Abe . Y . Nishimura . J . Nawata . H . Watanabe . T . Muta . K . free .
• Tsuneizumi M . Overrepresentation of the EBAG9 gene at 8q23 associated with early-stage breast cancers . Clin. Cancer Res. . 7 . 11 . 3526–32 . 2002 . 11705872 . Emi M . Nagai H . Harada . H . Sakamoto . G . Kasumi . F . Inoue . S . Kazui . T . Nakamura . Y .
• Umeoka K . Immunohistochemical analysis of RCAS1 in human pituitary adenomas . Mod. Pathol. . 14 . 12 . 1232–6 . 2002 . 11743045 . 10.1038/modpathol.3880467 . Sanno N . Oyama K . Tahara . Shigeyuki . Kurotani . Reiko . Ikuyama . Shoichiro . Nakashima . Manabu . Watanabe . Takeshi . Osamura . R. Yoshiyuki . free .
• Hiraoka K . High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker . Int. J. Cancer . 99 . 3 . 418–23 . 2002 . 11992411 . 10.1002/ijc.10381 . Hida Y . Miyamoto M . Oshikiri . Taro . Suzuoki . Masato . Nakakubo . Yoshihiro . Shinohara . Toshiya . Itoh . Tomoo . Shichinohe . Toshiaki . 38086160 . free .
• Rousseau J . RCAS1 is associated with ductal breast cancer progression . Biochem. Biophys. Res. Commun. . 293 . 5 . 1544–9 . 2002 . 12054692 . 10.1016/S0006-291X(02)00401-1 . Têtu B . Caron D . Malenfant . Patrick . Cattaruzzi . Paola . Audette . Marie . Doillon . Charles . Tremblay . Jacques P . Guérette . Benoit .
• Oizumi S . RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung . Oncology . 62 . 4 . 333–9 . 2002 . 12138241 . 10.1159/000065065 . Yamazaki K . Nakashima M . Watanabe . Takeshi . Hommura . Fumihiro . Ogura . Shigeaki . Nishimura . Masaharu . Dosaka-Akita . Hirotoshi . 21506683 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Engelsberg A . The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens . J. Biol. Chem. . 278 . 25 . 22998–3007 . 2003 . 12672804 . 10.1074/jbc.M301361200 . Hermosilla R . Karsten U . Schülein . R . Dörken . B . Rehm . A . free.
• Abe Y . Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis . Int. J. Hematol. . 77 . 4 . 359–63 . 2003 . 12774924 . 10.1007/BF02982644 . Ohshima K . Nakashima M . Hara . Keiichi . Matsushima . Takamitsu . Choi . Ilseung . Nishimura . Junji . Kikuch . Masahiro . Nawata . Hajime . 20918500 .
• Takahashi S . EBAG9/RCAS1 expression and its prognostic significance in prostatic cancer . Int. J. Cancer . 106 . 3 . 310–5 . 2003 . 12845666 . 10.1002/ijc.11205 . Urano T . Tsuchiya F . Fujimura . Tetsuya . Kitamura . Tadaichi . Ouchi . Yasuyoshi . Muramatsu . Masami . Inoue . Satoshi . 23545565 . free .
• Sonoda K . Association between RCAS1 expression and clinical outcome in uterine endometrial cancer . Br. J. Cancer . 89 . 3 . 546–51 . 2003 . 12888828 . 10.1038/sj.bjc.6601126 . 2394364 . Miyamoto S . Hirakawa T . Kaku . T . Nakashima . M . Watanabe . T . Akazawa . K . Fujita . T . Nakano . H .
• Leelawat K . Upregulation of tumour associated antigen RCAS1 is implicated in high stages of colorectal cancer . J. Clin. Pathol. . 56 . 10 . 764–8 . 2003 . 14514780 . 10.1136/jcp.56.10.764 . 1770069 . Watanabe T . Nakajima M . Tujinda . S . Suthipintawong . C . Leardkamolkarn . V .
• Ikeguchi M . Protein and gene expression of tumor-associated antigen RCAS1 in esophageal squamous cell carcinoma . Oncol. Rep. . 10 . 6 . 1891–4 . 2004 . 14534714 . 10.3892/or.10.6.1891. Ohoro S . Maeda Y . Yamaguchi . K . Fukuda . K . Shirai . H . Kondo . A . Tsujitani . S . Kaibara . N .
• Ikeguchi M, Hirooka Y, Kaibara N . Gene and protein expression of RCAS1 in hepatocellular carcinoma . Anticancer Res. . 23 . 6D . 4967–71 . 2004 . 14981953 .
• Brill LM . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d . Salomon AR . Ficarro SB . Mukherji . Mridul . Stettler-Gill . Michelle . Peters . Eric C. .

Notes and References

1. Web site: Entrez Gene: EBAG9 estrogen receptor binding site associated, antigen, 9.