EAF family explained

Symbol:	EAF
EAF
Pfam:	PF09816
Interpro:	IPR027093

In molecular biology, the EAF family of proteins act as transcriptional transactivators of ELL and ELL2 RNA Polymerase II (Pol II) transcriptional elongation factors.^{[1] [2] [3]} EAF proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. ELL and EAF1 are components of Cajal bodies, which have a role in leukemogenesis.^[2] EAF1 also has the capacity to interact with ELL1 and ELL2. The N terminus of approx 120 of EAF1 has a region of high serine, aspartic acid, and glutamic acid residues.^{[1] [4]}

Notes and References

1. Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ . EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein . Blood . 98 . 1 . 201–9 . July 2001 . 11418481 . 10.1182/blood.V98.1.201. 2577367 .
2. Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ . ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia . Mol. Biol. Cell . 14 . 4 . 1517–28 . April 2003 . 12686606 . 153119 . 10.1091/mbc.E02-07-0394 .
3. Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC . ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL . Proc. Natl. Acad. Sci. U.S.A. . 102 . 29 . 10094–8 . July 2005 . 16006523 . 1177379 . 10.1073/pnas.0503017102 . 2005PNAS..10210094K . free .
4. Banks CA, Kong SE, Spahr H, Florens L, Martin-Brown S, Washburn MP, Conaway JW, Mushegian A, Conaway RC . Identification and Characterization of a Schizosaccharomyces pombe RNA Polymerase II Elongation Factor with Similarity to the Metazoan Transcription Factor ELL . J. Biol. Chem. . 282 . 8 . 5761–9 . February 2007 . 17150956 . 10.1074/jbc.M610393200 . free .