Excitatory amino acid transporter 5 explained

Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.^{[1] [2]}

EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Wistow G, Bernstein SL, Ray S . Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. . Mol. Vis. . 8 . 185–95 . 2002 . 12107412 . etal.
• Boehmer C, Rajamanickam J, Schniepp R . Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3. . Biochem. Biophys. Res. Commun. . 329 . 2 . 738–42 . 2005 . 15737648 . 10.1016/j.bbrc.2005.02.035 . etal.
• Gratacòs M, Costas J, de Cid R . Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 150B . 6 . 808–16 . 2009 . 19086053 . 10.1002/ajmg.b.30902 . 44524739 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .

Notes and References

1. Web site: Entrez Gene: solute carrier family 1 (glutamate transporter).
2. Arriza JL, Eliasof S, Kavanaugh MP, Amara SG . Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance . Proc. Natl. Acad. Sci. U.S.A. . 94 . 8 . 4155–60 . April 1997 . 9108121 . 20584 . 10.1073/pnas.94.8.4155. 1997PNAS...94.4155A . free .