Hepatitis C virus envelope glycoprotein E2 explained

E2 is a viral structural protein found in the hepatitis C virus.^{[1] [2]} It is present on the viral envelope and functions as a host receptor binding protein, mediating entry into host cells. It is a key target for the design of entry inhibitors and vaccine immunogens.^[3]

Notes and References

1. Garcia JE, Puentes A, Súarez J, López R, Vera R, Rodríguez LE, Ocampo M, Curtidor H, Guzman F, Urquiza M, Patarroyo ME . Hepatitis C virus (HCV) E1 and E2 protein regions that specifically bind to HepG2 cells . Journal of Hepatology . 36 . 2 . 254–62 . 2002 . 11830338 . 10.1016/S0168-8278(01)00262-8 .
2. Bartosch B, Dubuisson J, Cosset FL . Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes . The Journal of Experimental Medicine . 197 . 5 . 633–42 . 2003 . 12615904. 2193821 . 10.1084/jem.20021756 .
3. Kong L, Giang E, Nieusma T, Kadam RU, Cogburn KE, Hua Y, Dai X, Stanfield RL, Burton DR, Ward AB, Wilson IA, Law M . Hepatitis C virus E2 envelope glycoprotein core structure . Science . 342 . 6162 . 1090–4 . 2013 . 24288331 . 3954638 . 10.1126/science.1243876 . 2013Sci...342.1090K .