E-site explained

The E-site is the third and final binding site for t-RNA in the ribosome during translation, a part of protein synthesis.^[1] The "E" stands for exit, and is accompanied by the P-site (for peptidyl) which is the second binding site, and the A-site (aminoacyl), which is the first binding site. It is involved in cellular processes.^[2]

Further reading

• Wilson . D. N. . Nierhaus . K. H. . The E-site story: the importance of maintaining two tRNAs on the ribosome during protein synthesis . Cellular and Molecular Life Sciences . December 2006 . 63 . 23 . 2725–2737 . 10.1007/s00018-006-6125-4. 11136154 .
• Nierhaus . K . Decoding errors and the involvement of the E-site . Biochimie . August 2006 . 88 . 8 . 1013–1019 . 10.1016/j.biochi.2006.02.009.

Notes and References

1. Chen. C.. Stevens. B.. Kaur. J.. Smilansky. Z.. Cooperman. B. S.. Goldman. Y. E.. 2011-10-03. Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis. Proceedings of the National Academy of Sciences. 108. 41. 16980–16985. 10.1073/pnas.1106999108. 21969541. 3193197. 2011PNAS..10816980C. 0027-8424. free.
2. Kirillov . S.V. . Makarov . E.M. . Semenkov . Yu.P. . Quantitative study of interaction of deacylated tRNA with Escherichia coli ribosomes: Role of 50 S subunits in formation of the E site . FEBS Letters . 27 June 1983 . 157 . 1 . 91–94 . 10.1016/0014-5793(83)81122-3.