SNTB1 explained

Beta-1-syntrophin is a protein that in humans is encoded by the SNTB1 gene.^{[1] [2] [3]}

Function

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally related genes.^[3]

Interactions

SNTB1 has been shown to interact with Dystrophin.^[4]

Further reading

• Ahn AH, Kunkel LM . Syntrophin binds to an alternatively spliced exon of dystrophin. . J. Cell Biol. . 128 . 3 . 363–71 . 1995 . 7844150 . 2120343 . 10.1083/jcb.128.3.363 .
• Yang B, Ibraghimov-Beskrovnaya O, Moomaw CR, Slaughter CA, Campbell KP . Heterogeneity of the 59-kDa dystrophin-associated protein revealed by cDNA cloning and expression. . J. Biol. Chem. . 269 . 8 . 6040–4 . 1994 . 10.1016/S0021-9258(17)37566-X . 8119949 . free .
• Ahn AH, Freener CA, Gussoni E, Yoshida M, Ozawa E, Kunkel LM . The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. . J. Biol. Chem. . 271 . 5 . 2724–30 . 1996 . 8576247 . 10.1074/jbc.271.5.2724 . free .
• Gee SH, Madhavan R, Levinson SR, Caldwell JH, Sealock R, Froehner SC . Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. . J. Neurosci. . 18 . 1 . 128–37 . 1998 . 9412493 . 6793384 . 10.1523/jneurosci.18-01-00128.1998.
• Hasegawa M, Cuenda A, Spillantini MG, Thomas GM, Buée-Scherrer V, Cohen P, Goedert M . Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. . J. Biol. Chem. . 274 . 18 . 12626–31 . 1999 . 10212242 . 10.1074/jbc.274.18.12626 . free .
• Blake DJ, Hawkes R, Benson MA, Beesley PW . Different dystrophin-like complexes are expressed in neurons and glia. . J. Cell Biol. . 147 . 3 . 645–58 . 1999 . 10545507 . 2151186 . 10.1083/jcb.147.3.645 .
• Newey SE, Benson MA, Ponting CP, Davies KE, Blake DJ . Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. . Curr. Biol. . 10 . 20 . 1295–8 . 2001 . 11069112 . 10.1016/S0960-9822(00)00760-0 . 18104833 . free .
• Marchand S, Stetzkowski-Marden F, Cartaud J . Differential targeting of components of the dystrophin complex to the postsynaptic membrane. . Eur. J. Neurosci. . 13 . 2 . 221–9 . 2001 . 11168526 . 10.1046/j.1460-9568.2001.01373.x .
• Hogan A, Shepherd L, Chabot J, Quenneville S, Prescott SM, Topham MK, Gee SH . Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. . J. Biol. Chem. . 276 . 28 . 26526–33 . 2001 . 11352924 . 10.1074/jbc.M104156200 . free .
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER . NotI flanking sequences: a tool for gene discovery and verification of the human genome. . Nucleic Acids Res. . 30 . 14 . 3163–70 . 2002 . 12136098 . 135748 . 10.1093/nar/gkf428 .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. . J. Biol. Chem. . 279 . 21 . 22331–46 . 2004 . 15024025 . 10.1074/jbc.M400285200 . free .
• Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW . Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. . J. Biol. Chem. . 280 . 47 . 39653–64 . 2006 . 16192269 . 10.1074/jbc.M510187200 . free .
• Kawai-Yamada M, Saito Y, Jin L, Ogawa T, Kim KM, Yu LH, Tone Y, Hirata A, Umeda M, Uchimiya H . A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae. . J. Biol. Chem. . 280 . 47 . 39468–73 . 2006 . 16192270 . 10.1074/jbc.M509632200 . free .
• Ejtehadi HD, Freimanis GL, Ali HA, Bowman S, Alavi A, Axford J, Callaghan R, Nelson PN . The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study. . Ann. Rheum. Dis. . 65 . 5 . 612–6 . 2006 . 16192292 . 1798125 . 10.1136/ard.2004.031146 .
• Chen Z, Hague C, Hall RA, Minneman KP . Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. . J. Biol. Chem. . 281 . 18 . 12414–20 . 2006 . 16533813 . 10.1074/jbc.M508651200 . free .

Notes and References

1. Ahn AH, Yoshida M, Anderson MS, Feener CA, Selig S, Hagiwara Y, Ozawa E, Kunkel LM . Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24 . Proc Natl Acad Sci U S A . 91 . 10 . 4446–50 . Jun 1994 . 8183929 . 43802 . 10.1073/pnas.91.10.4446 . 1994PNAS...91.4446A . free .
2. Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P . The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins . Oncogene . 16 . 5 . 643–54 . Mar 1998 . 9482110 . 10.1038/sj.onc.1201567 . free .
3. Web site: Entrez Gene: SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1).
4. Ahn AH, Kunkel LM . Syntrophin binds to an alternatively spliced exon of dystrophin . J. Cell Biol. . 128 . 3 . 363–71 . Feb 1995 . 7844150 . 2120343 . 10.1083/jcb.128.3.363 .