Hydrochlorothiazide/triamterene explained

Type:combo
Component1:Hydrochlorothiazide
Class1:Thiazide diuretic
Component2:Triamterene
Class2:Potassium-sparing diuretic
Tradename:Dyazide, Maxzide, others
Dailymedid:Hydrochlorothiazide and triamterene
Pregnancy Au:C
Routes Of Administration:By mouth
Atc Prefix:C03
Atc Suffix:EA01
Legal Us:Rx-only
Cas Number:14124-50-6
Kegg:D10269
Synonyms:co-triamterzide

Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a fixed-dose combination medication of hydrochlorothiazide and triamterene.[1] It is used to treat high blood pressure and edema (swelling).[1] Specifically it is used in those who develop low blood potassium (hypokalemia) when on only hydrochlorothiazide. It is taken by mouth.[1]

Side effects may include nausea, trouble sleeping, dizziness, feeling light headed with standing, kidney problems, allergies, and muscle cramps. Other serious side effects may include high blood potassium. Use in pregnancy and breastfeeding is not generally recommended. Use in those with significant kidney problems is not recommended. It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost.[2] [3]

The combination was approved for medical use in the United States in 1965.[4] In 2021, it was the 112th most commonly prescribed medication in the United States, with more than 5million prescriptions.[5] [6]

Notes and References

  1. Book: British national formulary : BNF 76. 2018. Pharmaceutical Press. 9780857113382. 76. 76.
  2. Web site: Dyazide- hydrochlorothiazide and triamterene capsule . DailyMed . 31 October 2017 . 20 August 2020.
  3. Web site: Maxzide-25- maxzide tablet Maxzide tablet . DailyMed . 20 July 2018 . 20 August 2020.
  4. Web site: Dyazide: FDA-Approved Drugs . U.S. Food and Drug Administration (FDA) . 20 August 2020.
  5. Web site: The Top 300 of 2021 . ClinCalc . 14 January 2024 . 15 January 2024 . https://web.archive.org/web/20240115223848/https://clincalc.com/DrugStats/Top300Drugs.aspx . live .
  6. Web site: Hydrochlorothiazide; Triamterene - Drug Usage Statistics . ClinCalc . 14 January 2024.