| Birth Date: | May 6, 1962 |
| Birth Place: | Miami, Florida, U.S. |
| Position: | Safety |
| High School: | Miami Central Senior (FL) |
| College: | Oklahoma |
| Databasefootball: | DRANEDWI01 |
| Pfr: | DranDw20 |
| Playing Years1: | 1986–1991 |
| Playing Team1: | Buffalo Bills |
Dwight Drane (born May 6, 1962) is a retired professional American football safety for the Buffalo Bills of the National Football League.
He was selected by the Buffalo Bills in the 1984 NFL Supplemental Draft of USFL and CFL Players, and subsequently proceeded to anchor the Bills' defensive backfield from 1986 to 1991.[1]