Dutasteride/tamsulosin explained

Dutasteride/tamsulosin, sold under the brand name Jalyn among others, is a medication produced by GlaxoSmithKline for the treatment of adult male symptomatic benign prostatic hyperplasia (BPH).^[1] It is a combination of two previously existing medications: dutasteride, brand name Avodart, and tamsulosin, brand name Flomax. It contains 0.5 mg of dutasteride and 0.4 mg of tamsulosin hydrochloride.

Jalyn was the result of the CombAT (Combination of Avodart and Tamsulosin) trial of 2008. It was approved by the U.S. Food and Drug Administration (FDA) on June 14, 2010.^[2] In June 2011, the FDA approved a label change to warn of "Increased Risk of High-grade Prostate Cancer" from Jalyn.^[3]

External links

• Web site: Dutasteride mixture with tamsulosin . U.S. National Library of Medicine . Drug Information Portal .

Notes and References

1. Keating GM . Dutasteride/tamsulosin: in benign prostatic hyperplasia . Drugs & Aging . 29 . 5 . 405–19 . May 2012 . 22550968 . 10.2165/11208920-000000000-00000 . 209142875 .
2. Web site: Center for Drug Evaluation and Research . Food and Drug Administration . 14 June 2010 . Approval Package for: Dutasteride 0.5 mg/Tamsulosin hydrochloride 0.4 mg .
3. Web site: Detailed View: Safety Labeling Changes: Jalyn (dutasteride and tamsulosin) capsules . June 2011 . Center for Drug Evaluation and Research . U.S. Food and Drug Administration . https://web.archive.org/web/20120106092520/https://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm262877.htm . 6 January 2012 .