| Adolphus Frederick IV | |
| Duke of Mecklenburg-Strelitz | |
| House: | House of Mecklenburg |
| Father: | Duke Charles Louis Frederick of Mecklenburg |
| Mother: | Princess Elisabeth Albertine of Saxe-Hildburghausen |
| Birth Place: | Mirow |
| Death Place: | Neustrelitz |
Adolphus Frederick IV (German: Adolf Friedrich IV; 5 May 1738 – 2 June 1794) was Duke of Mecklenburg-Strelitz from 1752 to his death in 1794.
He was born in Mirow to Duke Charles Louis Frederick of Mecklenburg and his wife Princess Elisabeth Albertine of Saxe-Hildburghausen. His father was the second son of Adolphus Frederick II, Duke of Mecklenburg.[1]
He was the heir presumptive of Mecklenburg-Strelitz from the death of his father on 5 June 1752 until he succeeded his uncle Duke Adolphus Frederick III on 11 December 1752. In the early years after 1753, his mother Princess Elisabeth Albertine of Saxe-Hildburghausen served as regent, as her son was only 14 years old. They were additionally under the protection of King George II of Great Britain.
In 1753, he studied at the University of Greifswald.
In 1761, his sister Charlotte married King George III of Great Britain.
In 1764, he was installed as a member of the Order of the Garter.
Adolphus Frederick never married. Following his death at Neustrelitz in 1794, he was succeeded by his brother Charles.