| Dudley Williams | |
| Honorific Suffix: | FRS |
| Birth Name: | Dudley Howard Williams |
| Birth Date: | 25 May 1937 |
| Birth Place: | Farsley, West Riding of Yorkshire, England |
| Death Place: | Cambridge, England |
| Fields: | Chemistry Organic Chemistry |
| Workplaces: | Cambridge |
| Education: | Pudsey Grammar School |
| Alma Mater: | Leeds University (BSc, 1958 PhD, 1961) |
| Thesis1 Title: | and |
| Thesis2 Title: | )--> |
| Thesis1 Url: | and |
| Thesis2 Url: | )--> |
| Thesis1 Year: | and |
| Thesis2 Year: | )--> |
| Doctoral Advisor: | Basil Lythgoe |
| Academic Advisors: | Carl Djerassi |
| Notable Students: | Jeremy K M Sanders |
| Awards: | See list |
| Spouse: | Lorna Patricia Phyllis Bedford |
| Partners: | )--> |
| Children: | 2 |
Dudley Howard Williams (25 May 1937 – 3 November 2010) was a British biochemist known for utilizing nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry in the study of molecular structure, especially the antibiotic vancomycin.[1] [2] [3]
Dudley Howard Williams was born on 25 May 1937 in Farsley, Yorkshire, the only child of Lawrence Williams, an engineers chief order clerk,[4] and Evelyn (née Hudson). He attended Pudsey Grammar School, from where he gained a place at the University of Leeds. He graduated in 1958 with a first-class BSc in Chemistry.[2]
Williams' research for a PhD was on the synthesis of Vitamin D and related compounds, under the supervision of Basil Lythgoe, FRS at Leeds; his degree was awarded in 1961. That same year he was awarded a Fulbright Scholarship and moved to Stanford University to work with Carl Djerassi exploring the application of mass spectrometry (MS) in organic chemistry. He used the evenings to investigate the use of nuclear magnetic resonance (NMR) on a 100 MHz instrument with Norman Bhacca at nearby Varian Associates. "In three stunningly productive years, he showed how mass spectrometry and NMR … could transform the way that organic chemists worked. His textbooks, reviews, research papers and lectures revolutionised organic chemistry over the following years".[5]
In December 1962 Djerassi gave Williams three months' leave to go back to England to marry Lorna Patricia Phyllis (always known as Pat) Bedford, whom he had met at Leeds. She was a secretary in the Chemistry department. They married on 9 March 1963 and travelled to California, which they enjoyed exploring in their leisure time.
The next move was to Cambridge in 1964, to take up a junior position in Organic Chemistry, at the invitation of Lord Todd. A condition of the move was that the department should buy a Varian 100 MHz NMR spectrometer and an AEI MS9 mass spectrometer. Williams stayed at Cambridge until his retirement in 2004.
In his memoir of Dudley Williams, Sanders noted that "the different areas of [his] science overlapped, intertwined and evolved so it is not easy to separate them out for discussion".[2] He summarized Williams' work in three areas
Dudley and Pat had two sons, Mark Howard in 1966 and Simon Bedford in 1968.Williams retired in 2004. Six years later he was diagnosed with an aggressive carcinoma of the liver. He died in a hospice in Cambridge on 3 November 2010.