| Duchess Luise | |
| Princess Augustus William of Prussia | |
| Issue: | Frederick William II of Prussia Prince Henry Wilhelmina, Princess of Orange Prince Emil |
| Father: | Ferdinand Albert II, Duke of Brunswick-Wolfenbüttel |
| Mother: | Duchess Antoinette of Brunswick-Wolfenbüttel |
| Birth Date: | 29 January 1722 |
| Birth Place: | Schloss Bevern, Weser |
| Death Place: | Schloss Oranienburg, Berlin, Prussia |
Duchess Luise of Brunswick-Wolfenbüttel (Luise Amalie; 29 January 1722 – 13 January 1780) was daughter of Ferdinand Albert II, Duke of Brunswick-Wolfenbüttel and his wife Duchess Antoinette of Brunswick-Wolfenbüttel.
She was born at the Schloss Bevern near Weser. She was the seventh of fourteen children. Her parents were second cousins.
On 6 January 1742 she married Prince Augustus William of Prussia, second son of King Frederick William I of Prussia and Sophia Dorothea of Hanover. Prince Augustus William was a younger brother of the reigning Frederick the Great, whose spouse, Luise's own sister, gave him no children. As such, her son was to inherit the Prussian throne in 1786. In her widowhood, she was given the Crown Prince's Palace in Berlin.
Her older sister was Queen Elisabeth Christine of Prussia, wife of her brother-in-law Frederick the Great. She was also the sibling of Queen Juliana Maria of Denmark and Norway and Charles I, Duke of Brunswick-Wolfenbüttel.