Dubois Creek is a stream in Franklin County in the U.S. state of Missouri. It is a tributary to the Missouri River.
The headwaters arise at 38.4808°N -91.0417°W and the confluence with the Missouri is at 38.5397°N -90.9558°W. The stream source area is along the east side of Missouri Route A between Union and Krakow. The stream flows northeast passing under Route 47 and then north passing under Route 100 to enter the Missouri floodplain just east of Washington.[1]
Dubois Creek most likely was named after Louis Dubois, an early French frontiersman.[2]