| Duan Zhigui | |
| Birth Date: | 段芝贵 1869 |
| Death Date: | 1925 |
| Birth Place: | Hefei, Anhui, Qing dynasty |
| Death Place: | Tianjin, Republic of China |
| Allegiance: | Republic of China Empire of China |
| Rank: | General |
| Awards: | Order of the Rising Sun Order of Wen-Hu Order of the Precious Brilliant Golden Grain Order of Rank and Merit |
| Laterwork: | Minister of War |
Duan Zhigui (; pronounced as /cmn/ 1869 – March 1925) was a Chinese general. Born in Hefei, Anhui, he attained the post of Heilongjiang governor in the late Qing dynasty and between 1912 and 1913 was governor of Chahar and the military governor of Hubei between 1914 and 1915, as well as military and civil governor of Fengtian in 1915–16.
A staunch supporter of Yuan Shikai, he was nicknamed the "Adopted Prince", and when Duan Qirui, a fellow Hefei native, took the Beijing government in 1917, Duan was made a Minister of War;[1] however, with Duan Qirui's defeat by 1920, Duan Zhigui fled to the Japanese embassy. He was remitted in 1922 and lived in Tianjin until his death there in 1925.