Drupanol Explained

Drupanol is a naturally occurring phenol that has been isolated from the seeds of Psoralea drupaceae.^{[1] [2]} Although drupanol is sometimes said to be the same compound as bakuchiol, the two compounds are in fact distinct; they have the same molecular formula and weight but different chemical structures and hence are structural isomers. Bakuchiol has been found to possess antiandrogenic activity in vitro.^[3]

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 120,473.
2. Golovina LA, Nikonov GK . The structure of drupanol — A new phenol from Psoralea drupaceae. Chemistry of Natural Compounds. 9. 1. 1973. 7–9. 0009-3130. 10.1007/BF00580876. 4813778.
3. Miao L, Ma SW, Fan GW, Wang H, Wang YF, Chai LJ . Bakuchiol inhibits the androgen induced-proliferation of prostate cancer cell line LNCaP through suppression of AR transcription activity. . Tianjin Journal of Traditional Chinese Medicine . 2013 . 5 . 012 .