Droxicam Explained

Droxicam is a non-steroidal anti-inflammatory drug of the oxicam class. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.[1]

Synthesis

When heated, phenyl pyridin-2-ylcarbamate (1) decomposes to 2-isocyanatopyridine (2) which reacts with the heterocyclic compound (3) to give droxicam.[2] [3] [4]

Notes and References

  1. Jané F, Rodríguez de la Serna A . Droxicam: a pharmacological and clinical review of a new NSAID . European Journal of Rheumatology and Inflammation . 11 . 4 . 3–9 . 1991 . 1365488 .
  2. US . 4563452 . Jose M. Ribalta-Baro and Jordi F. Rigola-Constansa . Benzothiazine derivatives and their applications as medicinal products or as synthesis intermediates for medicinal products . patent . 1992-07-21 . 1990-07-31 . Laboratorios del Dr Esteve SA.
  3. Web site: Droxicam . Thieme . 2024-07-04.
  4. Web site: Droxicam . chemdrug.com . 2024-07-04.

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