Drofenine Explained

Drofenine is an antimuscarinic antispasmodic drug used for relaxing smooth muscle, thereby treating conditions, such as: dysmenorrhea, and pain in the gastrointestinal tract, biliary passages, and urogenital tract. Drofenine is assumed to work by increasing the levels of the protein TRPV3.[1] [2] [3]

Notes and References

  1. Kunysz EL, Michel AD, Whiting RL . Functional and direct binding studies using subtype selective muscarinic receptor antagonists . British Journal of Pharmacology . 93 . 3 . 491–500 . March 1988 . 2897216 . 10.1111/j.1476-5381.1988.tb10303.x . 1853838 .
  2. Bodur E, Cokuğraş AN, Tezcan EF . Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase . Archives of Biochemistry and Biophysics . 386 . 1 . 25–9 . February 2001 . 11360997 . 10.1006/abbi.2000.2188 .
  3. Deering-Rice CE, Mitchell VK, Romero EG, Abdel Aziz MH, Ryskamp DA, Križaj D, Gopal VR, Reilly CA . 6 . Drofenine: A 2-APB Analogue with Greater Selectivity for Human TRPV3 . Pharmacology Research & Perspectives . 2 . 5 . e00062 . October 2014 . 25089200 . 10.1002/prp2.62 . 4115637 .

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