Doxpicomine Explained

Doxpicomine (Doxpicodin, Doxpizodine) is a mild opioid analgesic drug.[1] The drug acts as a mu-opioid receptor agonist.[2] It is of fairly low potency, with a 400 mg dose of doxpicomine approximately equivalent in pain-killing effect to 8 mg morphine or 100 mg pethidine.[3] [4] It has been used as a lead compound to derive further analogues, although all compounds in this family are comparatively weak mu agonists.[5]

Notes and References

  1. US . 3905987 . patent . m-Dioxane-5-Methylamine Analgesics . Booher RN . Eli Lilly . 09/16/1975 .
  2. Smits SE, Nickander R, Booher RN, Zimmerman DM, Wong DT, Hynes MD, Pohland A . Preclinical pharmacology of doxpicodin, a new analgesic . NIDA Research Monograph . 34 . 75–81 . February 1981 . 6261137 .
  3. Wang RI, Robinson N . Doxpicomine in postoperative pain . Clinical Pharmacology and Therapeutics . 29 . 6 . 771–5 . June 1981 . 7014073 . 10.1038/clpt.1981.109 . 24849960 .
  4. Wang RI, Robinson N . Further efficacy evaluation of doxpicomine for postoperative pain . Journal of Clinical Pharmacology . 23 . 1 . 44–7 . January 1983 . 6341416 . 10.1002/j.1552-4604.1983.tb02703.x . 36306783 .
  5. Wünsch B, Bauschke G . [Benzomorphan analogs with doxpicomine partial structure: synthesis andpsychopharmacologic investigations of 5-aminomethyl- and 5-(alpha-aminobenzyl)- substituted 2,6-epoxy-3-benzoxocines] . German . Archiv der Pharmazie . 326 . 3 . 171–80 . March 1993 . 8481096 . 10.1002/ardp.19933260311 . 98749966 . Benzomorphan analogs with doxpicomine partial structure: synthesis and psychopharmacologic investigations of 5-aminomethyl- and 5-(alpha-aminobenzyl)- substituted 2,6-epoxy-3-benzoxocines .

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