Doxercalciferol Explained

Doxercalciferol (or 1-hydroxyergocalciferol, trade name Hectorol) is drug for secondary hyperparathyroidism and metabolic bone disease.[1] It is a synthetic analog of ergocalciferol (vitamin D2). It suppresses parathyroid synthesis and secretion.[2]

Doxercalciferol is the vitamin D2 analogue of alfacalcidol.[3] It undergoes 25-hydroxylation in the liver to become the active ercalcitriol, without the involvement of kidneys.[4]

Notes and References

  1. Sprague S M . Ho L T . Oral doxercalciferol therapy for secondary hyperparathyroidism in a peritoneal dialysis patient . Clinical Nephrology . 2002 . 58 . 2 . 155–160 . 10.5414/cnp58155 . 12227689.
  2. Web site: Doxercalciferol . Drugs.com.
  3. Upton. R. A.. Knutson. J. C.. Bishop. C. W.. LeVan. L. W.. Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone. Nephrology Dialysis Transplantation. 1 April 2003. 18. 4. 750–758. 10.1093/ndt/gfg030. 12637645 . free.
  4. Web site: HECTOROL INJECTION (doxercalciferol). FDA accessdata. 21 April 2018.

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