- Old Post Office, 300 East Main Street, 30.0041°N -91.8166°W, built c.1903. Also listed in East Main Street Historic District.
- Pascal Building, 223 East Main Street, 30.0046°N -91.8165°W, built 1889. Also individually listed.
- Leblanc & Broussard Ford Dealership, 221 East Main Street, 30.0047°N -91.8166°W, built c.1912.
- Leblanc & Broussard Service Department Warehouse, 221½ East Main Street, 30.005°N -91.8163°W, built 1931.
- Davis Building, 133 East Main Street, 30.0051°N -91.8173°W, built 1892.
- Bayou Teche Museum, 131 East Main Street, 30.0052°N -91.8173°W, built 1929-30.
- Evangeline Theater, 129 East Main Street, 30.0053°N -91.8174°W, built 1929-30. Also individually listed.
- Crystal Image, 115 East Main Street, 30.0053°N -91.8174°W.
- Crystal Image, 115 East Main Street, 30.0056°N -91.8177°W.
- Provost's Café, 113 East Main Street, 30.0057°N -91.8178°W. Also known as Armand's and Clementine's Fine Dining.
- Building at 111 East Main Street, 30.0057°N -91.8178°W.
- Building at 109 East Main Street, 30.0058°N -91.8179°W.
- Coleman Building, 105 East Main Street, 30.0059°N -91.818°W.
- DeRouen Financial, 103 East Main Street, 30.006°N -91.818°W.
- Renoudet Building, 101 East Main Street, 30.006°N -91.818°W.
- Building at 144 West Main Street, 30.0071°N -91.8191°W. Built 1941.
- Building at 144A West Main Street, 30.0072°N -91.819°W. Built 1941.
- McMahon Furniture Company, 150 West Main Street, 30.0073°N -91.8193°W. Built 1890.
- Satterfield Building, 152 West Main Street, 30.0073°N -91.8193°W. Built 1881.
- Chevron (Gulf) Service Station, 200 West Main Street, 30.0076°N -91.8196°W. Built 1927.
- Riviere's Jewelry Store, 214 West Main Street, 30.0076°N -91.8197°W. Built 1940s.
- Slim's News Stand, 216 West Main Street, 30.0077°N -91.8197°W. Built 1940s.
| - Iberia Steam Laundry, 220 West Main Street, 30.0078°N -91.8198°W.
- Steinberg Building, 232 West Main Street, 30.0081°N -91.8201°W. Built c.1880.
- American Department Store, 254 West Main Street, 30.0086°N -91.8205°W. Built 1950s.
- Hebert's Hotel, 213-225 West Main Street, 30.0077°N -91.8202°W.
- John R. Taylor Drugstore, 145 West Main Street, 30.007°N -91.8196°W. Built 1907. Also individually listed.
- Bayou Art Gallery, 143 West Main Street, 30.0068°N -91.8194°W. Built 1870s.
- Armentor's Jewelry Store, 137 West Main Street, 30.0067°N -91.8193°W.
- Abdalla's Department Store, 131 West Main Street, 30.0065°N -91.8194°W. Built 1950s-1960s.
- Napoleon's on the Teche, 127 West Main Street, 30.0064°N -91.8193°W. Built 1950s-1960s.
- Abdalla's Department Store Building #3, 131A West Main Street, 30.0064°N -91.8192°W. Built 1950s-1960s.
- People's National Bank, 119 West Main Street, 30.0063°N -91.819°W. Built 1911. Also individually listed.
- Building at 109 West Main Street, 30.0061°N -91.8188°W.
- Model Company, 107 West Main Street, 30.006°N -91.8188°W.
- Building at 105 West Main Street, 30.006°N -91.8187°W.
- Gougenheim Building, 101 West Main Street, 30.0059°N -91.8187°W. Built c.1893. Also known as Hugonin Building and Morgan & Lindsay.
- Bowab's, 102 East Main Street, 30.0057°N -91.8185°W. Built c.1893.
- Creims, 104 East Main Street, 30.0057°N -91.8184°W. Built c.1893.
- Babineaux's Shoes, 108 East Main Street, 30.0055°N -91.8183°W.
- Ackal's Department Store, 110 East Main Street, 30.0055°N -91.8183°W.
- Wormser's Department Store, 112-116 East Main Street, 30.0053°N -91.8182°W. Built 1932. Also individually listed.
- Building at 120 East Main Street, 30.0052°N -91.818°W. Built 1950s.
- Building at 122 East Main Street, 30.0051°N -91.818°W. Built 1950s.
- Bazus Building, 210 East Main Street, 30.0045°N -91.8172°W.
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