Douglas Scherr Explained

Douglas S. Scherr (born January 7, 1967) is an American surgeon and specialist in Urologic Oncology. He is currently the Clinical Director of Urologic Oncology at Weill Cornell Medicine.^[1] He also holds an appointment at the Rockefeller University as a Visiting Associate Physician. Scherr was the first physician at Cornell to perform a robotic prostatectomy as well as a robotic cystectomy.^[2] ^[3]

Background

A native of New York, Scherr studied at Cornell University and received an undergraduate degree in government. Scherr spent a year abroad in Shenyang, China, after which he attended medical school at the George Washington University School of MedicineWashington, D.C. Subsequently, he completed a 6-year residency in Urology at the New York-Presbyterian Hospital and a Fellowship in Urologic Oncology at Memorial Sloan Kettering Cancer Center for two years. He is married to Jennifer Scherr and they have three children.

Areas of focus

Scherr specializes in treating urologic malignancies. His focus is on the treatment of prostate cancer, bladder cancer, kidney cancer, testicular cancer, and genitourinary and retroperitoneal sarcomas. He performs robotic assisted removal of bladders with total bladder reconstructions, along with colleague Shahrokh Shariat.

He sits on several advisory boards in companies involved in urologic technology development. He has been influential in the ergonomics of robotic technology. He has been active in the development of optical coherence tomography and its application to urologic imaging.

Also active in the Laboratory of Urologic Oncology, Scherr has been instrumental in defining the hormonal regulation of bladder cancer and is currently developing a novel class of compounds that utilize the innate immune system to fight urologic tumors. He is working on the development of a non-invasive means to assess human tissue at the microscopic level. To this end, he has patented and developed the concept of “multiphoton endoscopy” which utilizes high speed laser energy to create high quality microscopic images of human tissue. This breakthrough has vast applications in cystoscopy, colonoscopy and bronchoscopy.

Honors and awards

William Beaumont Medical Research Honor Society First Prize for Best Original Medical Essay, The William Shafirt Award, The George Washington University School of Medicine. “A crisis of unknown proportion: An empirical analysis of the American medical malpractice system.” 1994
First Prize for Clinical Investigation, Ferdinand C. Valentine Urology Residents Essay Meeting, “BCL-2 and P53 expression in clinically localized prostate cancer as predictive markers for the response to external beam radiotherapy.” 1998
First Prize for Clinical Investigation, Society of University Urology Residents, Annual Chief Resident Meeting, Marietta, Georgia. “Anti-androgen therapy for prostate cancer and the prevention of osteoporosis: The role of DES.” 2000
Second Prize for Clinical Investigation, Ferdinand C. Valentine Urology Residents Essay Meeting, “Collagen Type I Crosslinked N-Telopeptide as a urinary marker for osteoporosis in prostate cancer: The role of Diethylstilbesterol (DES).” 2000
Pfizer, Scholars in Urology Award, Awarded for advancing the scientific and clinical field of urology. 2000
Ferdinand C. Valentine Fellowship for Research in Urology. The New York Academy of Medicine. 2001–2002. Syndecan-1 expression in prostate cancer and the role of p27 in primary prostate epithelial cell transformation.
T32 Research Training Grant Memorial Sloan Kettering Cancer Center. 2000–2002.
Edwin Beer Research Award NY Academy of Medicine. Effective Tumor Immunotherapy in Transitional Cell Carcinoma of the Bladder. 2005-2007
Career Development Award Kidney Urology Foundation of America. The role of the Pim-1 Oncoprotein in Prostate Carcinogenesis. 2004-2005
Best Video Award Society of Laparoscopic Surgery. Oncological Outcomes of Robotic Cystectomy. San Francisco, CA August, 2007.

Publications

10.1016/j.urology.2006.09.065 . 17320658 . 2007 . Raman . JD . Sosa . RE . Vaughan Ed . Jr . Scherr . DS . Pathologic features of bladder tumors after nephroureterectomy or segmental ureterectomy for upper urinary tract transitional cell carcinoma . 69 . 2 . 251–4 . Urology.
10.1016/j.juro.2007.01.112 . 17509356 . 2007 . Smith . EB . Schwartz . M . Kawamoto . H . You . X . Hwang . D . Liu . H . Scherr . DS . Antitumor effects of imidazoquinolines in urothelial cell carcinoma of the bladder . 177 . 6 . 2347–51 . The Journal of Urology.
17092279 . 2007 . Barocas . DA . Mathew . Delpizzo . Vaughan Ed . Sosa . Fine . Akhtar . Scherr . Renal cell carcinoma sub-typing by histopathology and fluorescence in situ hybridization on a needle-biopsy specimen . 99 . 2 . 290–5 . 10.1111/j.1464-410X.2006.06607.x . BJU International . S . JJ . ED . RE . RG . M . DS. 27845456 . free .
17651548 . 2007 . Raman . JD . Dong . Levinson . Samadi . Scherr . Robotic Radical Prostatectomy: Operative Technique, Outcomes, and Learning Curve . 11 . 1 . 1–7 . JSLS . S . A . D . DS . 3015817.
17673914 . 2007 . Raman . JD . Scherr . Management of patients with upper urinary tract transitional cell carcinoma . 4 . 8 . 432–43 . 10.1038/ncpuro0875 . Nature Clinical Practice Urology . DS. 21351473 .
17888044 . 2008 . Wang . GJ . Barocas . Raman . Scherr . Robotic vs open radical cystectomy: prospective comparison of perioperative outcomes and pathological measures of early oncological efficacy . 101 . 1 . 89–93 . 10.1111/j.1464-410X.2007.07212.x . BJU International . DA . JD . DS. 10233606 .
18241249 . 2008 . Liu . H . Schwartz . Hwang . Scherr . Tumour growth inhibition by an imidazoquinoline is associated with c-Myc down-regulation in urothelial cell carcinoma . 101 . 7 . 894–901 . 10.1111/j.1464-410X.2008.07459.x . BJU International . MJ . DH . DS. 205538510 .
18330908 . 2008 . Schwartz . MJ . Hwang . Hung . Han . Mcclain . Shemtov . Te . Sosa . Vaughan Ed . Negative influence of changing biopsy practice patterns on the predictive value of prostate-specific antigen for cancer detection on prostate biopsy . 112 . 8 . 1718–25 . 10.1002/cncr.23353 . Cancer . DH . AJ . J . JW . MM . AE . RE . ED. Scherr . Douglas S. . 8 . free .
10.1111/j.1464-410X.2007.07410.x . 18257855 . 2008 . Richstone . L . Bianco . FJ . Shah . HH . Kattan . MW . Eastham . JA . Scardino . PT . Scherr . DS . Radical prostatectomy in men aged >or=70 years: effect of age on upgrading, upstaging, and the accuracy of a preoperative nomogram . 101 . 5 . 541–6 . BJU International. free .
17882221 . 2007 . Seandel . M . James . Shmelkov . Falciatori . Kim . Chavala . 2935199 . Scherr . Zhang . Torres . Generation of functional multipotent adult stem cells from GPR125+ germline progenitors . 449 . 7160 . 346–50 . 10.1038/nature06129 . Nature . D . SV . I . J . S . DS . F . R. Gale . Nicholas W. . Yancopoulos . George D. . Murphy . Andrew . Valenzuela . David M. . Hobbs . Robin M. . Pandolfi . Pier Paolo . Rafii . Shahin . 2007Natur.449..346S . 8 .
16336324 . 2006 . Barocas . DA . Rabbani . Scherr . Vaughan Ed . A population-based study of renal cell carcinoma and prostate cancer in the same patients . 97 . 1 . 33–6 . 10.1111/j.1464-410X.2005.05880.x . BJU International . F . DS . ED. 10616104 .
10.1016/j.juro.2006.07.038 . 17070218 . 2006 . Barocas . DA . Rohan . SM . Kao . J . Gurevich . RD . Del Pizzo . JJ . Vaughan Ed . Jr . Akhtar . M . Chen . YT . Scherr . DS . Diagnosis of renal tumors on needle biopsy specimens by histological and molecular analysis . 176 . 5 . 1957–62 . The Journal of Urology .
17575752 . 2006 . Raman . JD . Palese . Ng . Boorjian . Scherr . Del Pizzo . Sosa . Hand-Assisted Laparoscopic Nephroureterectomy for Upper Urinary Tract Transitional Cell Carcinoma . 10 . 4 . 432–8 . JSLS . MA . CK . SA . DS . JJ . RE . 3015762.
10.1016/j.urology.2004.11.047 . 15882726 . 2005 . Shelton . JB . Barocas . DA . Conway . F . Hart . K . Nelson . K . Richstone . L . Gonzalez . RR . Raman . JD . Scherr . DS . Prostate-specific antigen screening in a high-risk population: lessons from the community and how they relate to large-scale population-based studies . 65 . 5 . 931–6 . Urology .
10.1016/j.urology.2005.02.022 . 16098357 . 2005 . Boorjian . S . Ng . C . Munver . R . Palese . MA . Vaughan Ed . Jr . Sosa . RE . Del Pizzo . JJ . Scherr . DS . Impact of delay to nephroureterectomy for patients undergoing ureteroscopic biopsy and laser tumor ablation of upper tract transitional cell carcinoma . 66 . 2 . 283–7 . Urology.
10.1016/j.urology.2005.06.039 . Unified theory of prostate cancer: the role of steroid 5 alpha reductase and steroid aromatase . 2005 . Pittsjr . W . Scherr . Urology . 66 . 11–12 . D . 3.
10.1016/j.urology.2005.06.079 . 16286153 . 2005 . Barocas . DA . Kawamoto . H . Dreizin . DF . Howard . ME . Choi . J . Pitts . WR . You . X . Tickoo . SK . Boorjian . SA . Scherr . Douglas S. . Five-alpha-reductase expression in benign and malignant urothelium: correlation with disease characteristics and outcome . 66 . 5 . 1134–9 . Urology. 8 .
16361539 . 2005 . Raman . JD . Mongan . Tickoo . Boorjian . Scherr . Gudas . Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder . 11 . 24 Pt 1 . 8570–6 . 10.1158/1078-0432.CCR-05-1047 . Clinical Cancer Research . NP . SK . SA . DS . LJ. free .
16225523 . 2005 . Raman . JD . Ng . Boorjian . Vaughan Ed . Sosa . Scherr . Bladder cancer after managing upper urinary tract transitional cell carcinoma: predictive factors and pathology . 96 . 7 . 1031–5 . 10.1111/j.1464-410X.2005.05804.x . BJU International . CK . SA . ED . RE . DS. 26096624 .
10.1093/carcin/bgi299 . 16344273 . 2006 . Raman . JD . Mongan . NP . Liu . L . Tickoo . SK . Nanus . DM . Scherr . DS . Gudas . LJ . Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma . 27 . 3 . 499–507 . Carcinogenesis. free .
15754000 . 2005 . Boorjian . S . Scherr . Mongan . Zhuang . Nanus . Gudas . Retinoid receptor mRNA expression profiles in human bladder cancer specimens . 26 . 4 . 1041–8 . International Journal of Oncology . DS . NP . Y . DM . LJ . 10.3892/ijo.26.4.1041.
15659932 . 2004 . Boorjian . S . Ng . Munver . Palese . Sosa . Vaughan . Del Pizzo . Scherr . Abnormal selective cytology results predict recurrence of upper-tract transitional-cell carcinoma treated with ureteroscopic laser ablation . 18 . 9 . 912–6 . 10.1089/end.2004.18.912 . Journal of Endourology . C . R . MA . RE . ED . JJ . DS.
10.1097/01.ju.0000106955.19813.f6 . 14713772 . 2004 . Richstone . L . Scherr . DS . Reuter . VR . Snyder . ME . Rabbani . F . Kattan . MW . Russo . P . Multifocal renal cortical tumors: frequency, associated clinicopathological features and impact on survival . 171 . 2 Pt 1 . 615–20 . The Journal of Urology.
15161698 . 2004 . Boorjian . S . Tickoo . Mongan . Yu . Bok . Rando . Nanus . Scherr . Gudas . Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer . 10 . 10 . 3429–37 . 10.1158/1078-0432.CCR-03-0756 . Clinical Cancer Research . SK . NP . H . D . RR . DM . DS . LJ . free .
10.1016/j.urology.2004.03.025 . 15302512 . 2004 . Boorjian . S . Ugras . S . Mongan . NP . Gudas . LJ . You . X . Tickoo . SK . Scherr . DS . Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer . 64 . 2 . 383–8 . Urology.
10.1007/s11934-004-0014-x . Treatment of adrenocortical carcinoma: Contemporary outcomes . 2004 . Chen . David Y. T. . Sosa . Scherr . Current Urology Reports . 5 . 65–72 . 14733841 . RE . DS . 1. 41696275 .
10.1016/S0090-4295(02)02395-6 . National Comprehensive Cancer Network guidelines for the management of prostate cancer . 2003 . Scherr . D . Urology . 61 . 14–24 . 12667883 . Swindle . PW . Scardino . PT . National Comprehensive Cancer Network . 2 Suppl 1.
10.1016/S0090-4295(03)00773-8 . Practice patterns among urologic surgeons treating localized renal cell carcinoma in the laparoscopic age: technology versus oncology . 2003 . Scherr . Douglas S. . Ng . Munver . Sosa . Vaughan Jr . Del Pizzo . Urology . 62 . 1007–11 . 14665345 . C . R . RE . ED . J . 6.
10.1097/01.ju.0000077558.48257.3d . 14532759 . 2003 . Scherr . DS . Pitts Wr . Jr . The nonsteroidal effects of diethylstilbestrol: the rationale for androgen deprivation therapy without estrogen deprivation in the treatment of prostate cancer . 170 . 5 . 1703–8 . The Journal of Urology.
10.1016/S0090-4295(02)01954-4 . High expression of the Met receptor in prostate cancer metastasis to bone☆ . 2002 . Knudsen . Beatrice S . Gmyrek . Inra . Scherr . Vaughan . Nanus . Kattan . Gerald . Vande Woude . Urology . 60 . 1113–7 . 12475693 . GA . J . DS . ED . DM . MW . WL . GF . 6 .
10.1016/S0022-5347(01)69080-3 . Diethylstilbesterol Revisited: Androgen Deprivation, Osteoporosis and Prostate Cancer . 2002 . Scherr . D . Pittsjr . Vaughanjr . The Journal of Urology . 167 . 535–8 . 11792913 . WR . ED . 2 Pt 1.
11828354 . 2002 . Scherr . DS . Eastham . Ohori . Scardino . Prostate biopsy techniques and indications: when, where, and how? . 20 . 1 . 18–31 . Seminars in Urologic Oncology . 10.1053/suro.2002.30395 . J . M . PT.
10.1016/S0022-5347(05)67561-1 . Renal Transplantation After in Vivo Excision of an Angiomyolipoma from a Living Unrelated Kidney Donor . 2000 . Chen . A . Scherr . Eid . The Journal of Urology . 163 . 1859 . 10799200 . D . JF . 6.
10.1016/S0022-5347(05)68615-6 . ERRATA . 1999 . The Journal of Urology . 162 . 503 . 2.
10.1097/00005392-199907000-00003 . 10379729 . 1999 . Scherr . DS . Vaughan Ed . Jr . Wei . J . Chung . M . Felsen . D . Allbright . R . Knudsen . BS . BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy . 162 . 1 . 12–6; discussion 16–7 . The Journal of Urology.
10.1097/00005392-199907000-00021 . 10379746 . 1999 . Scherr . D . Goldstein . M . Comparison of bilateral versus unilateral varicocelectomy in men with palpable bilateral varicoceles . 162 . 1 . 85–8 . The Journal of Urology.
10.1016/S0094-0143(05)70439-0 . Laser Tissue Welding . 1998 . Scherr . D . Poppas . Urologic Clinics of North America . 25 . 123–35 . 9529543 . DP . 1.
9873775 . 1998 . Poppas . DP . Scherr . Laser tissue welding: a urological surgeon's perspective . 4 . 4 . 456–62 . Haemophilia . 10.1046/j.1365-2516.1998.440456.x . DS. 1078110 .
Neoadjuvant Chemotherapy for Invasive Bladder Cancer: Prognostic Factors for Survival of Patients Treated with M-VAC with Five-Year Follow-Up . Journal of Clinical Oncology . 1994 . 12 . 1394–1401 . 8021730 . 7 . Schultz, PK . Herr, HW . Zhang, ZF . Bajorin, DF . Seidman, A . Sarkis, A . Fair, WR . Scherr, D . Bosl, GJ. 8 . Scher . H. I. . 10.1200/JCO.1994.12.7.1394 .

External links

PubMed search for Douglas S. Scherr

Notes and References

Web site: Dr. Douglas Scherr SPORE in Prostate Cancer . 2022-10-20 . prostatespore.weill.cornell.edu.
Web site: Robotic Surgery Extends Benefits to Bladder Cancer Patients at NewYork-Presbyterian/Weill Cornell . 2022-10-20 . WCM Newsroom . en.
Web site: 2016-06-30 . Douglas S. Scherr, M.D. . 2022-10-20 . What's New in GU? . en.