Douglas R. Lowy Explained

Douglas R. Lowy
Field:Cancer biology
Awards:Lasker-DeBakey Clinical Medical Research Award (2017) Sabin Gold Medal (2011)

Douglas R. Lowy (born 1940s) is the current Principal Deputy Director of the U.S. National Cancer Institute (NCI) and Chief of the Laboratory of Cellular Oncology within the Center for Cancer Research at NCI. Lowy served as Acting Director of NCI between April 2015 and October 2017 following the resignation of Harold E. Varmus, M.D., [1] [2] and again between April and November 2019, while Director Norman Sharpless served as the Acting Commissioner of the U.S. Food and Drug Administration.[3] He resumed the role of Acting Director on May 1, 2022, when Sharpless stepped down until October 3, 2022 when Monica Bertagnolli was appointed Director.[4] [5] He resumed the role again in November 2023 after Bertagnolli resigned to serve as director of the National Institutes of Health.[6]

Lowy has served as Deputy Director of the NCI since 2010, alongside former directors Varmus and Sharpless and current director Bertagnolli.[7] Lowy was co-recipient (along with Dr. John T. Schiller) of the National Medal of Technology and Innovation in 2014[8] and the Lasker-DeBakey Clinical Medical Research Award in 2017.

Biography

Lowy received his medical degree from the New York University School of Medicine, and trained in internal medicine at Stanford University and dermatology at Yale. He has directed a research laboratory at NCI since 1975, after receiving training as a Research Associate in the National Institute of Allergy and Infectious Diseases. Lowy is a member of the National Academy of Sciences (NAS) and of its Institute of Medicine. For his joint research with John T. Schiller on technology that enabled the development of preventive human papillomavirus (HPV) vaccines, he and Schiller received the 2007 Samuel J. Heyman Service to America Medal,[9] the 2011 Albert B. Sabin Gold Medal,[10] the 2012 National Medal of Technology and Innovation (awarded in 2014), and the Lasker-DeBakey Clinical Medical Research Award in 2017. He has also received the National Medal of Honor for Basic Research from the American Cancer Society.[11]

Research activities

Lowy's HPV research, conducted in collaboration with John T. Schiller, has characterized the HPV oncoproteins E6 and E7.[12] [13]

Awards

External links

Notes and References

  1. Web site: Douglas Lowy named Acting Director of the National Cancer Institute. Website of the National Cancer Institute. April 2015 . 1 April 2015.
  2. News: Chief of National Cancer Institute Resigns . Sabrina . Tavernise . March 4, 2015 . . 16 July 2015.
  3. News: National Cancer Chief, Ned Sharpless, Named F.D.A.'s Acting Commissioner. Kaplan. Sheila. 2019-03-12. The New York Times. 2019-03-17. en-US. 0362-4331.
  4. Web site: Monica Bertagnolli becomes NCI director - NCI . 3 October 2022 .
  5. Web site: 2019-11-01 . NCI Acting Director Dr. Douglas R. Lowy - National Cancer Institute . 2022-05-02 . www.cancer.gov . en.
  6. Web site: Monica Bertagnolli, M.D., takes the helm at NIH . 9 November 2023 .
  7. Web site: 2019-11-01 . NCI Principal Deputy Director Dr. Douglas R. Lowy - National Cancer Institute . 2022-03-24 . www.cancer.gov . en.
  8. Web site: President Obama Presents the National Medals of Science & National Medals of Technology and Innovation. National Archives. whitehouse.gov. 20 November 2014 . 2 April 2015.
  9. Web site: 2007 Federal Employees of the Year. https://web.archive.org/web/20150108143245/http://servicetoamericamedals.org/SAM/recipients/profiles/fym07_lowy_schiller.shtml. January 8, 2015. Service to America Medals. 2015-04-02.
  10. Web site: Sabin Gold Medal Award. 2 April 2015.
  11. Web site: American Cancer Society to Present Highest Honor for Outstanding Contributions to Cancer Fight. American Cancer Society. 2 April 2015. https://web.archive.org/web/20150914170856/http://pressroom.cancer.org/index.php?s=43&item=71. 14 September 2015. dead.
  12. Androphy. EJ. Hubbert. NL. Schiller. JT. Lowy. DR. Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.. The EMBO Journal. April 1987. 6. 4. 989–92. 10.1002/j.1460-2075.1987.tb04849.x. 3036495. 553493.
  13. Hawley-Nelson. P. Vousden. KH. Hubbert. NL. Lowy. DR. Schiller. JT. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.. The EMBO Journal. 1 December 1989. 8. 12. 3905–10. 10.1002/j.1460-2075.1989.tb08570.x. 2555178. 402081.
  14. Web site: Douglas R. Lowy, MD. American Association for Cancer research . 16 July 2015.
  15. News: Work on Cervical Cancer Vaccine Puts NIH Duo in the Running for Major Award . . September 10, 2007 . Stephen . Barr. 16 July 2015.
  16. Web site: Laureates . Novartis Prizes for Immunology . 3 October 2011 . 29 August 2018 . https://web.archive.org/web/20180829175211/http://www.novartisimmunologyprizes.com/laureates/ . 29 August 2018 . dead .
  17. Web site: Douglas R. Lowy, MD, Receives Harrington Prize for Innovation in Medicine . ASCO Post . March 10, 2015 . 6. 4 . 16 July 2015.
  18. Lowy. Douglas R.. HPV vaccination to prevent cervical cancer and other HPV-associated disease: from basic science to effective interventions. Journal of Clinical Investigation. 4 January 2016. 126. 1. 5–11. 10.1172/JCI85446. 26727228. 4701560.
  19. Web site: HPV vaccines for cancer prevention The Lasker Foundation. Foundation. Lasker. The Lasker Foundation. en. 2018-06-19.
  20. Web site: Szent-Györgyi Prize to honor NCI's Douglas R. Lowy and John T. Schiller . 15 February 2018 . National Cancer Institute. 4 October 2019.

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