Douglas Higgs Explained

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Douglas Roland Higgs FRS (born 13 January 1951)[1] is a Professor of Molecular Haematology at the Weatherall Institute of Molecular Medicine, at the University of Oxford.[2] He is known for his work on the regulation of alpha-globin and the genetics of alpha-thalassemia. He is currently working in understanding the mechanisms by which any mammalian gene is switched on and off during differentiation and development.

Education

He was educated at Alleyn's School and qualified in medicine at King's College Hospital Medical School in 1974, and trained as a haematologist. He became a registrar in Haematology at Kings College Hospital in 1976.

Research and career

He joined the Molecular Haematology Unit of the Medical Research Council at Oxford in 1977. In 1996 he was appointed Ad Hominem Professor of Molecular Haematology. In 2001, he became a director of the MRC Molecular Haematology Unit (MHU).[3] In 2012, Higgs was appointed director of the Weatherall Institute of Molecular Medicine (WIMM).[4] In 2020, Higgs was succeeded as director of the MRC MHU and WIMM by Ketan J. Patel.[5] Higgs is a Senior Kurti Fellow at Brasenose College, Oxford.[6]

Honours and awards

Works

Gibbons. Richard J. Picketts. David J. Villard. Laurent. Higgs. Douglas R. Mutations in a putative global transcriptional regulator cause X-linked mental retardation with α-thalassemia (ATR-X syndrome). Cell. 80. 6. 837–845. 10.1016/0092-8674(95)90287-2. 7697714. 1995. 16411046. free.

Tufarelli. Cristina. Stanley. Jackie A Sloane. Garrick. David. Sharpe. Jackie A. Ayyub. Helena. Wood. William G. Higgs. Douglas R. 2003. Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease. Nature Genetics. 34. 2. 157–165. 10.1038/ng1157. 1546-1718. 12730694. 7226446.

Higgs. D. R.. Goodbourn. S. E. Y.. Lamb. J.. Clegg. J. B.. Weatherall. D. J.. Proudfoot. N. J.. 1983. α-Thalassaemia caused by a polyadenylation signal mutation. Nature. 306. 5941. 398–400. 10.1038/306398a0. 6646217. 1983Natur.306..398H . 4332750. 1476-4687.

Wilkie. Andrew O. M.. Lamb. Janette. Harris. Peter C.. Finney. Roger D.. Higgs. Douglas R.. 1990. A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n. Nature. 346. 6287. 868–871. 10.1038/346868a0. 1975428. 1990Natur.346..868W . 4239520. 1476-4687.

Nicholls. R.D.. Fischel-Ghodsian. N.. Higgs. D.R.. Recombination at the human α-globin gene cluster: Sequence features and topological constraints. Cell. 49. 3. 369–378. 10.1016/0092-8674(87)90289-3. 1987. 3032452. 54349888.

De Gobbi. Marco . Viprakasit. Vip. Hughes. Jim R.. Fisher. Chris. Buckle. Veronica J.. Ayyub. Helena. Gibbons. Richard J.. Vernimmen. Douglas. Yoshinaga. Yuko. 26 May 2006. A Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter. Science. 312. 5777. 1215–1217. 10.1126/science.1126431. 0036-8075. 16728641. 2006Sci...312.1215D . 16044469.

Law. Martin J.. Lower. Karen M.. Voon. Hsiao P.J.. Hughes. Jim R.. Garrick. David. Viprakasit. Vip. Mitson. Matthew. De Gobbi. Marco . Marra. Marco. ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner. Cell. 143. 3. 367–378. 10.1016/j.cell.2010.09.023. 21029860. 2010. free.

Hughes. Jim R. Roberts. Nigel. McGowan. Simon. Hay. Deborah. Giannoulatou. Eleni. Lynch. Magnus. De Gobbi. Marco . Taylor. Stephen. Gibbons. Richard. 2014. Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment. Nature Genetics. 46. 2. 205–212. 10.1038/ng.2871. 24413732. 2318/144575 . 205348099. 1546-1718. free.

Higgs. Douglas R.. Gibbons. Richard J.. McDowell. Tarra L.. Raman. Sundhya. O'Rourke. Delia M.. Garrick. David. Ayyub. Helena. 2000. Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nature Genetics. 24. 4. 368–371. 10.1038/74191. 10742099. 8847855. 1546-1718.

Hay. Deborah. Hughes. Jim R. Babbs. Christian. Davies. James O J. Graham. Bryony J. Hanssen. Lars L P. Kassouf. Mira T. Oudelaar. A Marieke. Sharpe. Jacqueline A. 2016. Genetic dissection of the α-globin super-enhancer in vivo. Nature Genetics. 48. 8. 895–903. 10.1038/ng.3605. 27376235. 1546-1718. 5058437.

Notes and References

  1. Book: Higgs, Prof. Douglas Roland. UK WHOS WHO. 2007. en. 10.1093/ww/9780199540884.013.244900. Higgs, Prof. Douglas Roland, (born 13 Jan. 1951), Professor of Haematology, since 1996, director, MRC Molecular Haematology Unit, since 2001, and director, Weatherall Institute of Molecular Medicine, since 2012, University of Oxford.
  2. Web site: Doug Higgs — WIMM . 25 March 2011 . https://web.archive.org/web/20110927150706/http://www.imm.ox.ac.uk/wimm-research/molhaem/doug-higgs . 27 September 2011 . dead .
  3. Web site: Top haematologist announced as new Director of MRC Weatherall Institute of Molecular Medicine. MRC. Medical Research Council. 18 May 2017. mrc.ac.uk. 16 March 2018.
  4. Web site: New Weatherall Institute of Molecular Medicine director announced – Weatherall Institute of Molecular Medicine. University of Oxford. 16 March 2018.
  5. Web site: MRC WIMM appoints new Director . 2023-12-01 . www.imm.ox.ac.uk . en.
  6. News: The Brazen Nose. 2009–2010.
  7. Web site: Professor Douglas Higgs The Academy of Medical Sciences. acmedsci.ac.uk. 16 March 2018. 17 March 2018. https://web.archive.org/web/20180317102408/https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-douglas-higgs. dead.
  8. Web site: Douglas Higgs. royalsociety.org. 16 March 2018.
  9. Web site: Buchanan Medal Awarded – Weatherall Institute of Molecular Medicine. University of Oxford. 16 March 2018. https://web.archive.org/web/20180317102043/https://www.imm.ox.ac.uk/buchanan-medal-awarded. 17 March 2018. dead.
  10. Web site: The Buchanan Medal (1897). The Royal Society. 12 September 2013.

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