| Dospat (Доспат, Δεσπάτης) | |
| Map: | Dospat River Map.png |
| Mouth Location: | Mesta/Nestos |
| Mouth Coordinates: | 41.3903°N 24.0875°W |
| Subdivision Type1: | Countries |
| Subdivision Name1: | Bulgaria and Greece |
| Length: | 110km (70miles) |
| Source1 Elevation: | 1610m (5,280feet) |
| Mouth Elevation: | 366m (1,201feet) |
| Basin Size: | 633.5km2 |
| Tributaries Left: | Sarnena |
| Tributaries Right: | Kochan, Osina |
The Dospat (;, Greek, Modern (1453-);: Despatis) is a river in the Western Rhodope Mountains, the most important tributary of the Mesta.
It takes its source from the 1643-metre-high Rozov vrah ("Rose Peak") in Bulgaria and flows southeast until Dospat Dam, after which it turns southwest to continue generally to the south and flow into the Mesta as a left tributary near the village Mikrokleisoura on Greek territory just south of the Greek-Bulgarian border.
The Dospat has a drainage basin of 633.5 km2. Its length is 110 km, of which 79 km is in Bulgaria[1] and 21 km in Greece. For a small distance of 3 km it forms the Greek–Bulgarian border.