Dorothea Fiedler Explained

Dorothea Fiedler
Doctoral Advisors:Kenneth N. Raymond, Robert G. Bergman
Academic Advisors:Kevan M. Shokat
Workplaces:Princeton University, Leibniz-Forschungsinstitut für Molekulare Pharmakologie

Dorothea Fiedler is a chemical biologist and also the first female director of the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (Leibniz Research Institute for Molecular Pharmacology, FMP) in Berlin, Germany.

Early life and education

Fiedler grew up in Hamburg.[1] She studied inorganic chemistry at the University of Würzburg,[2] then carried out doctorate research on organometallic chemistry at the University of California at Berkeley.[3]

Research and career

Although her PhD research focussed on organometallic chemistry[4] [5] including host-guest systems and applications to catalysis,[6] [7] Fiedler became interested in cellular signal transduction pathways during her postdoctoral research at the University of California, San Francisco.[8] She started her independent career as an assistant professor at Princeton University in 2010.[9] Her research focuses on the synthesis and signalling roles of inositol phosphates,[10] in particular, those with a pyrophosphate functionality,[11] [12] [13] [14] which has relevance to cellular signalling and cancer biology.[15] [16]

In 2015, Fiedler became the director of the Leibniz-Forschungsinstitut für Molekulare Pharmakologie as well as a professor of chemistry at the Humboldt University of Berlin.[17] She continues developing her research focus on the synthesis and signalling roles of protein modifications involving pyrophosphates,[18] [19] as well as building collaborations on biological chemistry and catalysis.[20]

Funding, service, and awards

Fiedler has received a New Innovator Award totalling over $2 million from the NIH in 2013.[21] She also received funding from the Sidney Kimmel Foundation for Cancer Research[22] [23] and the Rita Allen Foundation.[24] During her postdoctoral research, she received the Ernst Schering Foundation Postdoctoral Fellowship, was on the Fastrack Program of the Robert Bosch Foundation, and obtained an NIH Pathway to Independence Award.[25]

Fiedler is an invited speaker at the EMBO conference on Chemical Biology 2016[26] and at the International Symposium on Bioorganic Chemistry in 2017.[27]

Fiedler is one of the local organizers of the 42nd National Organic Chemistry Symposium by the organic division of the American Chemical Society in 2011.[28]

Notes and References

  1. Web site: FMP Berlin: Dorothea Fiedler is a new director at the FMP. www.leibniz-fmp.de. 2015-07-14. 2019-03-07.
  2. Web site: Dorothea Fiedler, Chemie, Humboldt-Universität Berlin. www.uni-wuerzburg.de. de. 2019-03-17.
  3. Web site: Dorothea Fiedler Gesellschaft Deutscher Chemiker e.V.. www.gdch.de. en. 2023-08-26.
  4. Fiedler. Dorothea. Pagliero. Daniela. Brumaghim. Julia L.. Bergman. Robert G.. Raymond. Kenneth N.. 2004-01-15. Encapsulation of Cationic Ruthenium Complexes into a Chiral Self-Assembled Cage. Inorganic Chemistry. 43. 3. 846–848. 10.1021/ic035105s. 14753801. 0020-1669.
  5. Fiedler. Dorothea. Leung. Dennis H.. Bergman. Robert G.. Raymond. Kenneth N.. 2004-03-06. Enantioselective Guest Binding and Dynamic Resolution of Cationic Ruthenium Complexes by a Chiral Metal−Ligand Assembly. Journal of the American Chemical Society. 126. 12. 3674–3675. 10.1021/ja039225a. 15038695. 0002-7863.
  6. Fiedler. Dorothea. van Halbeek. Herman. Bergman. Robert G.. Raymond. Kenneth N.. 2006-07-19. Supramolecular Catalysis of Unimolecular Rearrangements: Substrate Scope and Mechanistic Insights. Journal of the American Chemical Society. 128. 31. 10240–10252. 10.1021/ja062329b. 16881654. 0002-7863.
  7. Fiedler. Dorothea. Leung. Dennis H.. Bergman. Robert G.. Raymond. Kenneth N.. 2005-04-01. Selective Molecular Recognition, C−H Bond Activation, and Catalysis in Nanoscale Reaction Vessels. Accounts of Chemical Research. 38. 4. 349–358. 10.1021/ar040152p. 15835881. 2954569 . 0001-4842. 10.1.1.455.402.
  8. Fiedler. Dorothea. Braberg. Hannes. Mehta. Monika. Chechik. Gal. Cagney. Gerard. Mukherjee. Paromita. Silva. Andrea C.. Shales. Michael. Collins. Sean R.. 2009-03-05. Functional Organization of the S. cerevisiae Phosphorylation Network. Cell. 136. 5. 952–963. 10.1016/j.cell.2008.12.039. 2856666. 19269370.
  9. Book: Princeton Alumni Weekly. 2009-06-10. princeton alumni weekly.
  10. Web site: Research - Fiedler Group. www.princeton.edu. 2019-03-17. https://web.archive.org/web/20150906001012/http://www.princeton.edu/chemistry/fiedler/research/. 2015-09-06. dead.
  11. Web site: Lost in Post-Translation :: ChemViews Magazine :: ChemistryViews. Campbell. Meghan. 2015-02-05. www.chemistryviews.org. 2019-03-17.
  12. Wu. Mingxuan. Dul. Barbara E.. Trevisan. Alexandra J.. Fiedler. Dorothea. 2013. Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers. Chem. Sci.. 4. 1. 405–410. 10.1039/C2SC21553E. 2041-6520. 3558982. 23378892.
  13. Williams. Florence J.. Fiedler. Dorothea. 2015-09-18. A Fluorescent Sensor and Gel Stain for Detection of Pyrophosphorylated Proteins. ACS Chemical Biology. 10. 9. 1958–1963. 10.1021/acschembio.5b00256. 26061479. 1554-8929.
  14. Marmelstein. Alan M.. Yates. Lisa M.. Conway. John H.. Fiedler. Dorothea. 2014-01-08. Chemical Pyrophosphorylation of Functionally Diverse Peptides. Journal of the American Chemical Society. 136. 1. 108–111. 10.1021/ja411737c. 0002-7863. 3992712. 24350643.
  15. Shears. Stephen B.. 2014-10-05. Inositol pyrophosphates: Why so many phosphates?. Advances in Biological Regulation. 57. 203–216. 10.1016/j.jbior.2014.09.015. 4291286. 25453220.
  16. Shah. Akruti. Ganguli. Shubhra. Sen. Jayraj. Bhandari. Rashna. 2017-02-28. Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules. Journal of the Indian Institute of Science. 97. 1. 23–40. 10.1007/s41745-016-0011-3. 32214696. 7081659. 0970-4140. free.
  17. Web site: Humboldt-Universität zu Berlin - Dorothea Fiedler. agnes.hu-berlin.de. 2019-03-17.
  18. Yates. Lisa M.. Fiedler. Dorothea. 2016-04-15. A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins. ACS Chemical Biology. 11. 4. 1066–1073. 10.1021/acschembio.5b00972. 26760216. 1554-8929.
  19. Marmelstein. Alan M.. Morgan. Jeremy A. M.. Penkert. Martin. Rogerson. Daniel T.. Chin. Jason W.. Krause. Eberhard. Fiedler. Dorothea. 2018. Pyrophosphorylation via selective phosphoprotein derivatization. Chemical Science. 9. 27. 5929–5936. 10.1039/C8SC01233D. 2041-6520. 6050540. 30079207.
  20. Web site: UniSysCat: Signal-controlled multicomponent catalysis. www.unisyscat.tu-berlin.de. 2019-03-17. 2021-04-13. https://web.archive.org/web/20210413074700/https://www.unisyscat.tu-berlin.de/research-units/signal-controlled-multicomponent-catalysis.html. dead.
  21. Understanding phosphate metabolism in cancer and metastasis. Fiedler. Dorothea. 2013. Grantome. 2019-03-17.
  22. News: The Sidney Kimmel Foundation for Cancer Research Announces 2013 Grant Recipients. https://web.archive.org/web/20150222123658/http://www.prweb.com/releases/Sidney_Kimmel/cancer_research/prweb10774468.htm. dead. February 22, 2015. PRWeb. 2019-03-17.
  23. Web site: Our Scholars. Sidney Kimmel Foundation. 2019-03-17.
  24. Web site: Years 2013 - Rita Allen Foundation. 2019-03-17.
  25. Web site: UniSysCat: Fiedler, Dorothea. www.unisyscat.tu-berlin.de. 2019-03-17. 2021-04-13. https://web.archive.org/web/20210413084808/https://www.unisyscat.tu-berlin.de/group-leaders/fiedler-dorothea.html. dead.
  26. Web site: EMBO Conference - Chemical Biology 2016 - Speakers. www.embl.de. 2019-03-17.
  27. Web site: Speakers Programme International Symposium on Bioorganic Chemistry (ISBOC-11) & Konstanz Symposium Chemical Biology University of Konstanz. www.uni-konstanz.de. 2019-03-17.
  28. Web site: - NOS History. ACS Division of Organic Chemistry. 4 November 2016 . 2019-03-17.

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