Dora Richardson Explained

Dora Nellie Richardson (1919-1998) was a chemist who first synthesised Tamoxifen in England in 1962.[1] She was born on 1 June 1919 and died in September 1998 in England.[2]

Richardson decided to become a chemist after seeing people working in hospital laboratories while visiting her grandmother in hospital in London. She earned a Bachelor of Science in chemistry from University College London in 1941, and a PhD in 1953. Her dissertation in organic chemistry was on the synthesis of heterocyclic compounds.[3]

Richardson began her career at Imperial Chemical Industries in 1943, working there until her retirement. In the early 1960s, she worked on synthesising compounds, and separated the geometric isomers of a triphenylethylene, which developed the basis for Tamoxifen.[4] [5] In 1988, she published an article on the history of the development of Tamoxifen.[6]

Richardson was named on several patents.[7]

Notes and References

  1. Quirke . Viviane . Imperial Chemical Industries and Craig Jordan, "the First Tamoxifen Consultant," 1960s–1990s . . 2 July 2020 . 67 . 3 . 289–307 . 10.1080/00026980.2020.1794675 . free . 32706307 .
  2. Book: England and Wales Death Registration Index 1837-2007 . E13A . 5 November 2024 . Vol 0131E . . registration.
  3. Web site: The Forgotten Developer of Tamoxifen, a Lifesaving Breast Cancer Therapy . . 5 November 2024 . en . 24 October 2024 . Katie . Hafner . Marcy . Thompson.
  4. Jordan . VC . 50th anniversary of the first clinical trial with ICI 46,474 (tamoxifen): then what happened? . . January 2021 . 28 . 1 . R11–R30 . 10.1530/ERC-20-0335 . 33151906 . 7780369 .
  5. Bedford . G.R. . Richardson . D.N. . Preparation and Identification of cis and trans Isomers of a Substituted Triarylethylene . . 1966 . 212 . 5063 . 733-734 . 10.1038/212733b0 . 5 November 2024.
  6. Richardson . DN . The history of Nolvadex. . Drug Design and Delivery . July 1988 . 3 . 1 . 1–14 . 3076390.
  7. Web site: Dora N. Richardson Inventions, Patents and Patent Applications - Justia Patents Search . . 5 November 2024.

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