Avatrombopag Explained

Verifiedfields:changed
Watchedfields:changed
Width:200
Pronounce:a" va trom' boe pag
Tradename:Doptelet
Dailymedid:Avatrombopag
Pregnancy Au:B3
Routes Of Administration:By mouth
Atc Prefix:B02
Atc Suffix:BX08
Legal Au:S4
Legal Au Comment:[1] [2] [3]
Legal Ca:Rx-only
Legal Ca Comment:[4] [5]
Legal Us:Rx-only
Legal Us Comment:[6]
Legal Eu:Rx-only
Legal Status:Rx-only
Index2 Label:as salt
Cas Number:570406-98-3
Pubchem:9852519
Drugbank:DB11995
Chemspiderid:8028230
Unii:3H8GSZ4SQL
Kegg:D10306
Kegg2:D10307
Chembl:2103883
Iupac Name:1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
C:29
H:34
Cl:2
N:6
O:3
S:2
Smiles:C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl
Stdinchi:1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)
Stdinchikey:OFZJKCQENFPZBH-UHFFFAOYSA-N

Avatrombopag, sold under the brand name Doptelet, is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure.[7] [8] It was approved for medical use in the United States in May 2018,[9] [10] the European Union in June 2019,[11] and Australia in January 2023.

It acts as a thrombopoietin receptor agonist.[12]

Notes and References

  1. Web site: Doptelet . Therapeutic Goods Administration (TGA) . 30 January 2023 . 8 April 2023 . 5 February 2023 . https://web.archive.org/web/20230205203411/https://www.tga.gov.au/resources/auspmd/doptelet . live .
  2. Web site: Doptelet (Swedish Orphan Biovitrum Pty Ltd) . Therapeutic Goods Administration (TGA) . 16 February 2023 . 8 April 2023 . 27 March 2023 . https://web.archive.org/web/20230327062348/https://www.tga.gov.au/resources/prescription-medicines-registrations/doptelet-swedish-orphan-biovitrum-pty-ltd . live .
  3. Web site: AusPAR: Doptelet . Therapeutic Goods Administration (TGA) . 8 February 2024 . 31 March 2024.
  4. Web site: Details for: Doptelet . . 22 January 2024 . 3 March 2024 . 3 March 2024 . https://web.archive.org/web/20240303053753/https://dhpp.hpfb-dgpsa.ca/dhpp/resource/103124 . live .
  5. Web site: Summary Basis of Decision for Doptelet . . 17 May 2024 . 8 June 2024.
  6. Web site: Doptelet- avatrombopag maleate tablet, film coated . DailyMed . 1 July 2021 . 3 March 2024 . 3 March 2024 . https://web.archive.org/web/20240303053935/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e2d5960d-6c18-46cc-86bd-089222b09852 . live .
  7. Abdela J . Current Advance in Thrombopoietin Receptor Agonists in the Management of Thrombocytopenia Associated With Chronic Liver Disease: Focus on Avatrombopag . Clinical Medicine Insights. Blood Disorders . 12 . 1179545X19875105 . 2019 . 31673229 . 6804364 . 10.1177/1179545X19875105 .
  8. Markham A . Avatrombopag: A Review in Thrombocytopenia . Drugs . 81 . 16 . 1905–1913 . November 2021 . 34709601 . 8610948 . 10.1007/s40265-021-01613-y .
  9. FDA approves new drug for patients with chronic liver disease who have low blood platelets and are undergoing a medical procedure . U.S. Food and Drug Administration (FDA) . 21 May 2018 . 2 May 2020 . 11 December 2019 . https://web.archive.org/web/20191211204725/https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-patients-chronic-liver-disease-who-have-low-blood-platelets-and-are-undergoing . live .
  10. Web site: Drug Approval Package: Doptelet (avatrombopag) . U.S. Food and Drug Administration (FDA) . 28 June 2018 . 2 May 2020 . 7 April 2021 . https://web.archive.org/web/20210407143028/https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000TOC.cfm . live .
  11. Web site: Doptelet EPAR . European Medicines Agency (EMA) . 24 April 2019 . 2 May 2020 . 22 May 2020 . https://web.archive.org/web/20200522175116/https://www.ema.europa.eu/en/medicines/human/EPAR/doptelet . live .
  12. Kuter DJ . The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag . Blood Reviews . 53. 100909 . November 2021 . 34815110 . 10.1016/j.blre.2021.100909 . 244285488 . free .

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