Dopastin Explained

Dopastin is a chemical compound produced by the bacteria Pseudomonas No. BAC-125.[1] It was first isolated and characterized in 1972. It is an inhibitor of the enzyme dopamine β-hydroxylase.[2]

Dopastin can be prepared synthetically from L-valinol.[3]

Notes and References

  1. 4648494 . 1972 . Iimura . H . Takeuchi . T . Kondo . S . Matsuzaki . M . Umezawa . H . Dopastin, an inhibitor of dopamine -hydroxylase . 25 . 8 . 497–500 . The Journal of Antibiotics . 10.7164/antibiotics.25.497. free .
  2. Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase . H. Iinuma . M. Matsuzaki . T. Nagatsu . T. Takeuchi . H. Umezawa . Agric. Biol. Chem. . 1974 . 38 . 2107–2111 . 10.1271/bbb1961.38.2107 . 11. free .
  3. 10.1039/C39730000147 . Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin . 1973 . Ohno . M. . Iinuma . H. . Yagisawa . N. . Shibahara . S. . Suhara . Y. . Kondo . S. . Maeda . K. . Umezawa . H. . Journal of the Chemical Society, Chemical Communications . 4 . 147 .

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