| Ace Khuse | |
| Fullname: | Donald Themba Khuse |
| Birth Date: | 1963 9, df=y |
| Position: | Midfielder |
| Youthclubs1: | Lincoln City |
| Years1: | 1983–1986 |
| Years2: | 1986–1989 |
| Years3: | 1989–1993 |
| Years4: | 1993–1996 |
| Years5: | 1996–1997 |
| Clubs1: | Orlando Pirates |
| Clubs2: | Mamelodi Sundowns |
| Clubs3: | Kaizer Chiefs |
| Clubs4: | Gençlerbirliği |
| Clubs5: | Antalyaspor |
| Caps1: | 67 |
| Goals1: | 12 |
| Caps2: | 174 |
| Goals2: | 51 |
| Caps3: | 82 |
| Goals3: | 2 |
| Caps4: | 23 |
| Goals4: | 1 |
| Totalcaps: | 346 |
| Totalgoals: | 66 |
| Nationalyears1: | 1992–1995 |
| Nationalteam1: | South Africa |
| Nationalcaps1: | 16 |
| Nationalgoals1: | 0 |
| Manageryears1: | 1999– |
| Manageryears2: | 2012 |
| Managerclubs1: | Kaizer Chiefs (assistant) |
| Managerclubs2: | Kaizer Chiefs (interim) |
Donald Themba "Ace" Khuse (born 8 September 1963 in Johannesburg) is a retired South African association football player. Married to Innocentia Mampateng Motsumi, has a son Thabiso Khuse and daughter Nonhlahla Khuse.[1]